Determinants of blood eosinophilia in moderate and severe asthmatic patients during childhood: Evidence from the severe asthma molecular phenotype (SAMP) cohort
| Autor: | Philippe Saint-Pierre, Nathalie Cottel, Jocelyne Just, M. Bourgoin-Heck, Sarah Saf, Flore Amat, Nathalie C. Lambert, Tamazoust Guiddir |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Immunology Disease Immunoglobulin E 03 medical and health sciences Leukocyte Count 0302 clinical medicine Internal medicine Eosinophilia medicine Immunology and Allergy Humans 030212 general & internal medicine Prospective Studies Asthma biology business.industry Eosinophil medicine.disease 3. Good health Eosinophils medicine.anatomical_structure Cross-Sectional Studies Phenotype 030228 respiratory system Quartile Pediatrics Perinatology and Child Health Cohort biology.protein medicine.symptom business |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyREFERENCES. 32(6) |
| ISSN: | 1399-3038 |
| Popis: | BACKGROUND Asthma is a heterogeneous disease in which the interaction between genetic and environmental factors plays a major role. The significance of blood eosinophil is unclear. The aim of the study was to determine the significance of blood eosinophil count in moderate-to-severe asthmatic children of preschool age and school age. METHODS This was a prospective cross-sectional study performed from 2011 to 2015 including children from the severe asthma molecular phenotype (SAMP) cohort at Trousseau Hospital (Paris, France). We included children with severe and moderate asthma, or severe and moderate recurrent wheeze, aged from 1 to 15 years at the time of exploration. RESULTS We analyzed data from 402 children: 248 of preschool age and 154 of school age. Blood eosinophil count third quartile thresholds were 322 and 600 cells/μL for the preschool- and school-age groups, respectively. In multivariate analysis, a blood eosinophil count over this threshold was associated with elevated total IgE (OR = 5.33, P |
| Databáze: | OpenAIRE |
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