Improvement of mitochondrial function evaluated by ketoisocaproic acid breath test in patients with HCV infection undergoing albumin dialysis
| Autor: | Roberto Flore, Maria Assunta Zocco, Marcello Candelli, Paolo Pola, C. Di Campli, Enrico Celestino Nista, R. Gaspari, Giovanni Gasbarrini, Angelo Santoliquido, Paolo Tondi, G. Di Gioacchino, L. Zileri Dal Verme, Rodolfo Proietti, Antonio Gasbarrini |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Bilirubin medicine.medical_treatment Hemodiafiltration Chronic liver disease Gastroenterology Blood Urea Nitrogen Bile Acids and Salts chemistry.chemical_compound Internal medicine Medicine Humans Decompensation Blood urea nitrogen Caproates Dialysis Aged Breath test ketoisocaproic acid breath test Transplantation medicine.diagnostic_test business.industry Settore MED/09 - MEDICINA INTERNA Albumin Middle Aged medicine.disease Hepatitis C Keto Acids chemistry Breath Tests Creatinine Surgery Female business |
| Zdroj: | Transplantation proceedings. 37(6) |
| ISSN: | 0041-1345 |
| Popis: | Background and aim. Oxidative injury occurs as a direct result of hepatitis C virus (HCV) core protein expression both in vitro and in vivo, and may be due to a direct effect on mitochondria. The ketoisocaproic acid (KICA) breath test is a simple, reliable, and noninvasive test to evaluate hepatic mitochondrial function. Albumin dialysis (MARS) is an effective bridge treatment for patients with acute failure superimposed on chronic liver disease. The aim of our study was to evaluate the improvement of mitochondrial function measured by KICA in patients undergoing MARS for acute-on-chronic HCV liver failure. Materials and methods. Five patients with HCV chronic infection undergoing MARS treatment for acute decompensation were enrolled. Before and after each MARS treatment, patients underwent blood testing for the main hematochemical parameters as well as for mitochondrial function by the KICA breath test and the arterial ketone bodies ratio (AKBR). Results. MARS treatment effectively decreased the serum level of total bilirubin, bile acids, urea, and ammonium. Moreover, MARS treatment produced an increase in AKBR and in the cumulative percentage of 13 CO 2 recovered in exhaled air 2 hours after KICA ingestion. Conclusion. Liver mitochondrial function appears to be beneficially affected by MARS treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect