Persistent symptoms following SARS-CoV-2 infection amongst children and young people: A meta-analysis of controlled and uncontrolled studies
| Autor: | Sanaz A. Behnood, Shamez N Ladhani, Bianca DeStavola, Terence Stephenson, Roz Shafran, Russell M Viner, Alexa Xd Zhang, Olivia Swann, L O'Mahoney, Sophie Bennett |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
myalgia medicine.medical_specialty Abdominal pain paediatric Adolescent Fever Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Article Internal medicine Insomnia medicine Sore throat Humans Child long COVID Post-COVID syndrome Fatigue SARS-CoV-2 Children and Young People business.industry Headache Absolute risk reduction COVID-19 Study Characteristics Infectious Diseases Meta-analysis medicine.symptom business |
| Zdroj: | The Journal of Infection |
| ISSN: | 0163-4453 |
| Popis: | Background Data on the long-term impact of SARS-CoV-2 infection in children and young people (CYP) is conflicting. We assessed evidence on long-term post-COVID symptoms in CYP examining prevalence, risk factors, type and duration. Methods: Systematic search of published and unpublished literature using 13 online databases between 01/12/2019 – 31/07/2021. Eligible studies reported CYP ≤19 years with confirmed or probable SARS-CoV-2 with any symptoms persisting beyond acute illness. Random effects meta-analyses examined pooled risk difference in symptom prevalence (controlled studies only) and pooled prevalence (uncontrolled studies also included). Meta-regression examined study characteristics hypothesised to be associated with symptom prevalence. Prospectively registered: CRD42021233153. Findings Twenty two of 3357 unique studies were eligible, including 23,141 CYP. Median duration of follow-up was 125 days (IQR 99-231). Pooled risk difference in post-COVID cases compared to controls (5 studies) were significantly higher for cognitive difficulties (3% (95% CI 1, 4)), headache (5% (1, 8)), loss of smell (8%, (2, 15)), sore throat (2% (1, 2)) and sore eyes (2% (1, 3)) but not abdominal pain, cough, fatigue, myalgia, insomnia, diarrhoea, fever, dizziness or dyspnoea. Pooled prevalence of symptoms in post-COVID participants in 17 studies ranged from 15% (diarrhoea) to 47% (fatigue). Age was associated with higher prevalence of all symptoms except cough. Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms. Interpretation The frequency of the majority of reported persistent symptoms was similar in SARS-CoV-2 positive cases and controls. This systematic review and meta-analysis highlights the critical importance of a control group in studi7777es on CYP post SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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