Transient diffusion effects in the study of early platelet adhesion

Autor:	E. F. Leonard, Y. A. Butruille, R. S. Litwak, S. R. Savitz
Rok vydání:	1976
Předmět:	Surface Properties Chemistry Diffusion Platelet adhesion Biomedical Engineering Biocompatible Materials Nanotechnology Adhesion Sodium Chloride Stagnation point Models Biological Biomaterials Dogs Platelet Adhesiveness Time course Biophysics Animals Platelet Transient (oscillation) Mathematics
Zdroj:	Journal of Biomedical Materials Research. 10:145-160
ISSN:	1097-4636 0021-9304
DOI:	10.1002/jbm.820100113
Popis:	In the study of interactions of blood with artificial surfaces, it is common practice to wet these surfaces with a saline solution before exposing them to blood. The effect of this procedure on subsequent adhesion of blood platelets has been investigated both theoretically and experimentally, with a spinning disc apparatus. A large part of the observed delay in the initiation of platelet adhesion when using this apparatus is attributed to the time involved in displacing the prewetting fluid and bringing platelets near the surface. This observation is relevant to speculations of other researchers about the time course of adhesion-related reactions at the surface-proper. Other theoretical solutions are developed for the transient Leveque problem, which relates to a uniform shear-flow near a surface, and for a stagnation point apparatus. These solutions are compared with delay effects noticed in experimental data published by others.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8f7ac9d35d699f232429f81e91da6f https://doi.org/10.1002/jbm.820100113 Zobrazit plný text záznamu Plný text