Epidemiology and healthcare factors associated with neonatal enterococcal infections
| Autor: | Despoina Gkentzi, Christina Kortsalioudaki, Jim Buttery, Kenneth Tan, Joanna Wang, Paul Clarke, Paul T. Heath, Mark Anthony |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Infant Newborn Diseases Cohort Studies Sepsis 03 medical and health sciences 0302 clinical medicine Enterocolitis Necrotizing Intensive Care Units Neonatal 030225 pediatrics Internal medicine Epidemiology medicine Humans 030212 general & internal medicine Retrospective Studies Enterocolitis biology business.industry Australia Infant Newborn Obstetrics and Gynecology Retrospective cohort study Bacterial Infections General Medicine medicine.disease biology.organism_classification Anti-Bacterial Agents Europe Neonatal infection Parenteral nutrition Enterococcus Pediatrics Perinatology and Child Health Female Parenteral Nutrition Total medicine.symptom business Cohort study |
| ISSN: | 1468-2052 |
| Popis: | ObjectiveTo investigate the epidemiology and healthcare factors associated with late-onset neonatal enterococcal infections.DesignMulticentre, multinational retrospective cohort study using prospectively collected infection data from a neonatal infection surveillance network between 2004 and 2016; this was supplemented with healthcare data from a questionnaire distributed to participating neonatal units.SettingSixty neonatal units across Europe (UK, Greece, Estonia) and Australia.PatientsInfants admitted to participating neonatal units who had a positive culture of blood, cerebrospinal fluid or urine after 48 hours of life.ResultsIn total, 414 episodes of invasive Enterococcus spp infection were reported in 388 infants (10.1% of a total 4083 episodes in 3602 infants). Enterococcus spp were the second most common cause of late-onset infection after coagulase-negative Staphylococcus spp and were strongly associated with necrotising enterocolitis (NEC) (adjusted OR 1.44, 95% CI 1.02 to 2.03, p=0.038), total parenteral nutrition (TPN) (adjusted OR 1.34, 95% CI 1.06 to 1.70, p=0.016), increasing postnatal age (per 1-week increase: adjusted OR 1.04, 95% CI 1.02 to 1.06, pConclusionsEnterococcus spp were the second most frequent cause of late-onset infections. The association between enterococcal infections, NEC and TPN may inform empiric antimicrobial regimens in these contexts and provide insights into reducing these infections. |
| Databáze: | OpenAIRE |
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