High serum adiponectin levels predict incident falls among middle-aged and older adults: a prospective cohort study

Autor: Kaijun Niu, Atsushi Otomo, Cong Huang, Yufei Cui, Ryoichi Nagatomi, Haruki Momma, Masahiko Chujo
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Aging
Time Factors
Poison control
030204 cardiovascular system & hematology
Logistic regression
Body Mass Index
Cohort Studies
0302 clinical medicine
prevention
Japan
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Geriatrics
Aged
80 and over
education.field_of_study
Incidence
General Medicine
Middle Aged
Research Papers
biomarker
Female
medicine.medical_specialty
fall risk
Population
03 medical and health sciences
Age Distribution
Predictive Value of Tests
Internal medicine
medicine
Humans
Sex Distribution
education
Geriatric Assessment
Aged
geriatrics
Adiponectin
adiponectin
business.industry
Odds ratio
Confidence interval
Logistic Models
Multivariate Analysis
Physical therapy
Accidental Falls
Geriatrics and Gerontology
business
Biomarkers
Follow-Up Studies
Zdroj: Age and Ageing
ISSN: 1468-2834
0002-0729
Popis: BACKGROUND AND OBJECTIVE: adiponectin is an adipocyte-derived hormone with anti-obesity and anti-diabetic properties. However, higher circulating adiponectin levels are related to poor muscle function and physical disability, which suggests a potential link between adiponectin and risk of falls. Nevertheless, no direct association between circulating adiponectin levels and incident fall risk has been reported. Therefore, this study aimed to investigate the relationship between serum adiponectin levels and incident falls in a population of middle-aged and older adults. DESIGN: a prospective cohort study. SETTING: Oroshisho Center in Sendai City, Japan. SUBJECTS: Japanese adults who were ≥45 years old (n= 430). MEASUREMENTS: serum adiponectin levels were measured at baseline, and the subjects were divided into sex-specific tertiles. Data regarding a history of falls were collected via participant recall using a self-reported questionnaire. Incident falls were defined as falls that were experienced by people without a history of falls at baseline. RESULTS: during the 2-year follow-up, 15.6% (67/430) of the subjects experienced an incident fall. In the univariate logistic regression analysis, incident falls were significantly more frequent across the increasing sex-specific serum adiponectin tertiles (Pfor trend = 0.008). Adjusted odds ratios (95% confidence interval) for incident falls were 2.31 (1.07-4.98) in the middle tertile and 3.61 (1.63-7.99) in the highest tertile; this risk was significantly higher than that for the lowest adiponectin tertile (Pfor trend = 0.002). CONCLUSIONS: the findings of this prospective cohort study indicate that higher serum adiponectin levels may be a predictor of incident falls.© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. Language: en
Databáze: OpenAIRE
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