Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis
Autor: | Bruce Beutler, Octavio Ramilo, James P. Luby, George H. McCracken, Xavier Sáez-Llorens, Mahmoud M. Mustafa, Porter J, Kurt Olsen, Jussi Mertsola |
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Rok vydání: | 1990 |
Předmět: |
Pathology
medicine.medical_specialty Adolescent Inflammation Cerebrospinal fluid White blood cell medicine Humans Meningitis Meningitis Aseptic Child CSF albumin Tumor Necrosis Factor-alpha business.industry Infant Aseptic meningitis medicine.disease medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Tumor necrosis factor alpha Aseptic processing medicine.symptom business Interleukin-1 |
Zdroj: | Archives of Pediatrics & Adolescent Medicine. 144:349 |
ISSN: | 1072-4710 |
Popis: | Tumor necrosis factor-alpha and interleukin 1 beta have been shown to be mediators of meningeal inflammation in animal models of bacterial meningitis. The presence of both cytokines in cerebrospinal fluid (CSF) of patients with bacterial meningitis has been documented recently. In this study, we measured concentrations of interleukin 1 beta and tumor necrosis factor-alpha in CSF samples from 36 patients with nonbacterial (aseptic) meningitis, 13 of whom had culture-proved enteroviral meningitis, and from 14 control patients. None of the samples from patients with aseptic meningitis and from the controls had detectable tumor necrosis factor activity in CSF. Thirty-two (89%) of 36 patients with aseptic meningitis had detectable interleukin 1 beta in CSF (mean +/- SEM, 48 +/- 11 pg/mL). These concentrations were significantly smaller than those previously reported in patients with bacterial meningitis (944 +/- 128 pg/mL). Only 2 of the 14 control patients had detectable CSF interleukin 1 beta concentrations of 21 and 42 pg/mL. A significant correlation was evident between interleukin-1 beta concentrations and white blood cell counts in the CSF of patients with aseptic meningitis. Our data suggest that the initial events of CSF inflammation in children with aseptic meningitis are different than those in patients with bacterial meningitis, and the participation of these two cytokines, especially tumor necrosis factor-alpha, is less critical to the process. |
Databáze: | OpenAIRE |
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