Effect of histamine H3 receptor blockade on venous return and splanchnic hemodynamics in experimental bacteremia
| Autor: | Steven N. Mink, Edgar Bautista, Gregg Eschun, Krika Duke, Hans Jacobs, R. Bruce Light, Deepak Bose |
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| Rok vydání: | 2002 |
| Předmět: |
Cardiac function curve
Analysis of Variance Splanchnic Circulation business.industry Hemodynamics Histamine Antagonists Bacteremia Critical Care and Intensive Care Medicine Blockade Random Allocation Dogs Mean circulatory filling pressure Anesthesia Medicine Animals Receptors Histamine H3 Ventricular Function Histamine H3 receptor Splanchnic business Venous return curve Escherichia coli Infections |
| Zdroj: | Critical care medicine. 30(3) |
| ISSN: | 0090-3493 |
| Popis: | Objective: In the heart, histamine H 3 receptors may function as inhibitory presynaptic receptors that decrease adrenergic neural norepinephrine release in conditions of enhanced sympathetic tone. In a previous study, we found that H 3 receptor blockade improved cardiac contractility and systemic hemodynamics in experimental bacteremia in dogs. Because histamine H 3 receptors have been found in the splanchnic circulation in other animal models, it was not clear the extent to which H3 receptor blockade may have altered splanchnic hemodynamics, and variables of venous return, that in turn contributed to the overall improvement in systemic hemodynamics observed in the previous experiment. In the present study, we examined splanchnic hemodynamics in the presence of H3 receptor blockade in a canine model of Escherichia coli bacteremia. Design: Bacteremia was produced by intravenous infusion of live E. coli administered throughout the experiment. Variables of venous return included mean systemic pressure, resistance to venous return, and mean right atrial pressure. Splanchnic measurements included hepatic and portal pressures and flows. Measurements were obtained before and after H3 receptor blockade with thioperamide maleate. The animals were studied while ventilated and anesthetized. Results: H3 receptor blockade caused a decrease in mean right atrial pressure from 5.9 mm Hg pretreatment to 3.5 mm Hg posttreatment (p |
| Databáze: | OpenAIRE |
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