Association of inflammatory and oxidative stress biomarkers in subjects with cardiovascular risk
| Autor: | María Victoria Domínguez García, Eneida Camarillo-Romero, Araceli Amaya-Chávez, Abraham Majluf Cruz, Gerardo Huitrón Bravo, Angélica Jiménez-Rosales |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Vascular Cell Adhesion Molecule-1 Fibrinogen medicine.disease_cause Proinflammatory cytokine Superoxide dismutase Endothelial activation Risk Factors Internal medicine medicine Humans Pharmacology (medical) Endothelial dysfunction Pharmacology chemistry.chemical_classification Inflammation Reactive oxygen species biology business.industry Interleukin-6 Superoxide Dismutase General Medicine Middle Aged medicine.disease Oxidative Stress Endocrinology medicine.anatomical_structure Cross-Sectional Studies chemistry Cardiovascular Diseases biology.protein Female Endothelium Vascular business Oxidative stress Biomarkers medicine.drug |
| Zdroj: | American journal of therapeutics. 20(4) |
| ISSN: | 1536-3686 |
| Popis: | Cardiovascular disease is originated in the vascular endothelium, which controls the homeostasis and the filtration and diffusion of molecules from blood to the tissues. The classical cardiovascular risk factors (CRFs) act directly on the endothelium through an increase in the production of reactive oxygen species, promoting an endothelial activation mediated by the expression of adhesion and proinflammatory molecules, which lead to endothelial dysfunction, the progression of the atherosclerotic plaque, and the onset of cardiovascular disease. The objective of this study was to analyze the association of superoxide dismutase, catalase, gluthatione peroxidase, and lipoperoxidation with fibrinogen, interleukin (IL)-6, tumor necrosis factor-α, and vascular cell adhesion molecule (VCAM)-1 in subjects with cardiovascular risk (CVR) and CRF. This was a cross-sectional study of 114 individuals; oxidative stress (superoxide dismutase, catalase, gluthatione peroxidase, and lipoperoxidation) and inflammatory (fibrinogen, IL-6, tumor necrosis factor-α, and VCAM-1) biomarkers were measured; a CVR score (Framingham) and its CRF were taken into consideration to classify the participants. Twenty-nine subjects out of a total of 114 had high CVR. Smokers and subjects with diabetes (43 subjects) were excluded from the low CVR group. Significant decreases in lipoperoxidation, IL-6, and VCAM-1 and an increase in SOD were found in the high CVR group (P ≤ 0.05). Individual analysis of each CRF in the 114 subjects revealed a different pattern in the biomarkers' statistical differences. Concluding that the biomarkers show statistical differences in each CRF, especially IL-6, VCAM-1, and SOD; therefore, these are highly recommended to be used as biomarkers of the oxidative stress and inflammatory status in CVR. |
| Databáze: | OpenAIRE |
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