No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment
Autor: | Johannes Kornhuber, Oliver Peters, Katharina Bey, Jens Wiltfang, SG Riedel-Heller, Lardenoije R, Holger Wagner, E. Rüther, Michael Hüll, W. Maier, Bart P. F. Rutten, Milz E, Alfredo Ramirez, Ilker Karaca, Frank Jessen, Michael Wagner, J Becker, Martin Scherer, van den Hove Dl, Steffen Wolfsgruber, Lutz Frölich |
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Přispěvatelé: | Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Promovendi MHN |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Male Cancer Research psychology [Alzheimer Disease] genetics [Alzheimer Disease] Disease Bioinformatics 0302 clinical medicine Cognition Gene Frequency DNA (Cytosine-5-)-Methyltransferases Cognitive decline Aged 80 and over DNA methylation DNA methyltransferase 3A Alzheimer's disease Cohort Disease Progression Female psychology [Cognitive Dysfunction] medicine.medical_specialty DNA methyltransferase 3a Biology Polymorphism Single Nucleotide 03 medical and health sciences mild cognitive impairment Alzheimer Disease rs11887120 ddc:570 Internal medicine Genetics medicine SNP Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Epigenetics Genetic Association Studies Aged epigenetics genetics [DNA (Cytosine-5-)-Methyltransferases] aging genetics [Cognitive Dysfunction] cognitive decline MCI 030104 developmental biology Case-Control Studies DNMT3A 030217 neurology & neurosurgery |
Zdroj: | Epigenomics, 8(5), 593-598. Future Medicine Ltd. Epigenomics 8(5), 593-598 (2016). doi:10.2217/epi-2015-0014 |
ISSN: | 1750-1911 |
Popis: | Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI. |
Databáze: | OpenAIRE |
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