No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Autor: Johannes Kornhuber, Oliver Peters, Katharina Bey, Jens Wiltfang, SG Riedel-Heller, Lardenoije R, Holger Wagner, E. Rüther, Michael Hüll, W. Maier, Bart P. F. Rutten, Milz E, Alfredo Ramirez, Ilker Karaca, Frank Jessen, Michael Wagner, J Becker, Martin Scherer, van den Hove Dl, Steffen Wolfsgruber, Lutz Frölich
Přispěvatelé: Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Promovendi MHN
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Male
Cancer Research
psychology [Alzheimer Disease]
genetics [Alzheimer Disease]
Disease
Bioinformatics
0302 clinical medicine
Cognition
Gene Frequency
DNA (Cytosine-5-)-Methyltransferases
Cognitive decline
Aged
80 and over
DNA methylation
DNA methyltransferase 3A
Alzheimer's disease
Cohort
Disease Progression
Female
psychology [Cognitive Dysfunction]
medicine.medical_specialty
DNA methyltransferase 3a
Biology
Polymorphism
Single Nucleotide
03 medical and health sciences
mild cognitive impairment
Alzheimer Disease
rs11887120
ddc:570
Internal medicine
Genetics
medicine
SNP
Humans
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Epigenetics
Genetic Association Studies
Aged
epigenetics
genetics [DNA (Cytosine-5-)-Methyltransferases]
aging
genetics [Cognitive Dysfunction]
cognitive decline
MCI
030104 developmental biology
Case-Control Studies
DNMT3A
030217 neurology & neurosurgery
Zdroj: Epigenomics, 8(5), 593-598. Future Medicine Ltd.
Epigenomics 8(5), 593-598 (2016). doi:10.2217/epi-2015-0014
ISSN: 1750-1911
Popis: Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.
Databáze: OpenAIRE
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