Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis
| Autor: | Amaneh Hadadan, Seyed Reza Mirjalili, Razieh Sadat Tabatabaei, Reza Bahrami, Bahare Meibodi, Hossein Neamatzadeh, Atiyeh Javaheri, Mojgan Karimi-Zarchi, Hajar Abbasi, Neda Fatahi-Meibodi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
congenital hereditary and neonatal diseases and abnormalities Population 030105 genetics & heredity Bioinformatics Polymorphism Single Nucleotide Pathology and Forensic Medicine Encephalocele Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine medicine Humans Genetic Predisposition to Disease Neural Tube Defects education Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study Fetus 030219 obstetrics & reproductive medicine biology Spina bifida business.industry Neural tube General Medicine Publication bias medicine.disease digestive system diseases medicine.anatomical_structure Meta-analysis Methylenetetrahydrofolate reductase Case-Control Studies Pediatrics Perinatology and Child Health biology.protein Female business |
| Zdroj: | Fetal and pediatric pathology. 41(2) |
| ISSN: | 1551-3823 |
| Popis: | Background: MTHFR gene may be a key epigenetic regulation-related factor crucial during embryogenesis. We performed a meta-analysis to determine the association of fetal MTHFR C677T polymorphism with neural tube defects (NTDs).Methods: A comprehensive literature search of the PubMed, Embase, and CNKI database was performed up to April 10, 2020.Results: A total of 19 case-control studies with 2,228 NTDs cases and 4,220 controls were identified. Pooled data revealed that the fetal MTHFR C677T polymorphism was significantly highly correlated with development of NTDs in the overall population. Stratified analysis showed a significant association among Caucasians and Asians, but not in mixed populations. There was a significant association between the MTHFR C677T polymorphism and spina bifida risk. No publication bias was found under any genetic model.Conclusions: Our pooled data support the fetal MTHFR C677T polymorphism association with risk of NTDs, especially among Caucasians and Asians. |
| Databáze: | OpenAIRE |
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