Prepregnancy Genetic Carrier Screening in Recipients of Hematopoietic Stem Cell Transplants
| Autor: | Ashley Aluko, Alan S. Penzias, Emily A. Seidler |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
030219 obstetrics & reproductive medicine business.industry Genetic Carrier Screening media_common.quotation_subject Hematopoietic Stem Cell Transplantation Obstetrics and Gynecology Hematopoietic stem cell Chromosome Fertility Bioinformatics Young Adult 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Humans Medicine Female 030212 general & internal medicine business media_common |
| Zdroj: | Obstetrics & Gynecology. 134:756-758 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/aog.0000000000003456 |
| Popis: | BACKGROUND Genetic carrier screening of individuals with a history of hematopoietic stem cell (HSC) transplant is not always straightforward. CASE We present the case of a couple who underwent prepregnancy genetic screening before fertility treatment. The genetics laboratory flagged the male partner's blood sample because there was a discrepancy between the sex of the patient and the sex chromosome markers, ultimately leading to the discovery of a prior HSC transplant. CONCLUSION A history of HSC transplant may confound results of serum-based genetic carrier screening. Hematopoietic stem cell transplant recipients are at risk for misinterpreted genetic carrier screening because the results of such screening may not actually be reflective of their own DNA. |
| Databáze: | OpenAIRE |
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