Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats
| Autor: | Y Adenrele, Omonuyi O Omonua, Amos O. Abolaji, M U Eteng |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Erythrocytes
Antioxidant Artemether/lumefantrine Combination therapy Health Toxicology and Mutagenesis medicine.medical_treatment Glucosephosphate Dehydrogenase Pharmacology Toxicology Lumefantrine medicine.disease_cause Lipid peroxidation Antimalarials chemistry.chemical_compound Malondialdehyde medicine Animals Drug Interactions Artemether Rats Wistar Artemisinin Fluorenes Glutathione Peroxidase Superoxide Dismutase business.industry General Medicine Catalase Glutathione Artemisinins Rats Oxidative Stress chemistry Ethanolamines Female business Oxidative stress medicine.drug |
| Zdroj: | Human & Experimental Toxicology. 32:206-215 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327112464666 |
| Popis: | Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) has achieved excellent results in the fight against malarial scourge. In this study, we evaluated the toxic potential of these drugs at the therapeutic doses in female Wistar rats. Animals were randomly divided into four groups: those administered 1% Tween 80 (control), those administered artemether (4 mg/kg body weight), those administered lumefantrine (24 mg/kg body weight), and those coadministered artemether (4 mg/kg body weight) and lumefantrine (24 mg/kg body weight). The drugs were orally administered twice daily for 3 days by gastric intubation after which selected plasma biochemical indices, and erythrocytes antioxidant defence and lipid peroxidation markers were evaluated. Coadministration of artemether and lumefantrine raised liver and renal function markers and increased atherogenic index. While reduced glutathione, glucose-6-phosphate dehydrogenase (G6PD) and catalase activities were reduced, glutathione peroxidase and glutathione-s-transferase activities increased in all the treated groups compared to the control group. The drugs caused significant (p 0.05) elevation of malondialdehyde (MDA) levels compared to the control group. These results imply that coadministration of artemether and lumefantrine may increase the risks of atherosclerosis as well as liver and renal function impairments in the users. In addition, the drugs may also promote oxidative stress in the erythrocytes. |
| Databáze: | OpenAIRE |
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