Chemokines profile in patients with chronic heart failure treated with cardiac resynchronization therapy
| Autor: | Miroslaw Charkiewicz, Karol Charkiewicz, Karol Kamiński, Anna Szpakowicz, Piotr Laudanski, Włodzimierz J. Musiał, Ewa Tarasiuk, Marcin Jakub Kaminski, Marcin Witkowski, Marta Marcinkiewicz-Siemion, Katarzyna Ptaszyńska-Kopczyńska, Anna Lisowska, Emilia Sawicka |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Chemokine medicine.medical_treatment Cardiac resynchronization therapy Inflammation Gastroenterology Cardiac Resynchronization Therapy Pathogenesis 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans In patient 030212 general & internal medicine Aged Heart Failure Baseline values Ejection fraction biology business.industry General Medicine Middle Aged medicine.disease Treatment Outcome 030220 oncology & carcinogenesis Heart failure Chronic Disease biology.protein Female Chemokines medicine.symptom business Biomarkers Follow-Up Studies |
| Zdroj: | Advances in Medical Sciences. 65:102-110 |
| ISSN: | 1896-1126 |
| DOI: | 10.1016/j.advms.2019.11.007 |
| Popis: | Purpose Inflammatory mechanisms have been suggested to play a role in the heart failure with reduced ejection fraction (HF-REF) development, but the role of chemokines is largely unknown. Cardiac resynchronization therapy (CRT) may reverse the HF-REF course. We aimed to evaluate selected chemokines concentrations in HF-REF patients and their relationship with disease severity and clinical response to CRT. Materials and methods The study included 37 patients (64.1 ± 11.04 years, 6 females) with HF-REF subjected to CRT, controlled prior to implantation and after 6 months. The control population included 26 healthy volunteers (63.9 ± 8.1 years, 8 females). Serum chemokines concentrations were determined using multiplex method. Results HF-REF patients were characterized by the higher baseline MIF, NAP-2 and PF4 concentrations and lower Axl, BTC, IL-9, and IL-18 BPa concentrations comparing to controls. After 6 months of CRT only NAP-2 concentration decreased significantly in comparison to the baseline values. Conclusions HF-REF patients present altered chemokines profile compared to the control group. The CRT-related alleviation of HF-REF causes only slight changes in the chemokines concentrations especially in the platelet-associated ones. The precise chemokines role in the HF-REF pathogenesis and their prognostic value remains to be established. |
| Databáze: | OpenAIRE |
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