Beneficial Effects of Pterocarpan-High Soybean Leaf Extract on Metabolic Syndrome in Overweight and Obese Korean Subjects: Randomized Controlled Trial

Autor: Dong-Ha Shin, Eun-Young Kwon, Ji-Young Choi, Hyeon-Seon Ji, Tae-Sook Jeong, Ye Jin Kim, Myung-Sook Choi, Ri Ryu, Su-Jung Cho, Un Ju Jung
Rok vydání: 2016
Předmět:
Blood Glucose
Male
0301 basic medicine
Time Factors
Pterocarpans
Overweight
Body fat percentage
chemistry.chemical_compound
Nutrition and Dietetics
soybean leaf
Middle Aged
Lipids
Treatment Outcome
Female
Inflammation Mediators
medicine.symptom
lcsh:Nutrition. Foods and food supply
Signal Transduction
Adult
medicine.medical_specialty
mRNA sequencing
lcsh:TX341-641
Biology
Article
metabolic syndrome
03 medical and health sciences
Insulin resistance
Double-Blind Method
Internal medicine
Republic of Korea
medicine
Humans
Aged
Glycated Hemoglobin
Plants
Medicinal
Plant Extracts
Cholesterol
medicine.disease
Plant Leaves
030104 developmental biology
Endocrinology
MRNA Sequencing
Gene Expression Regulation
chemistry
inflammation
PBMCs
Leukocytes
Mononuclear
Soybeans
Hemoglobin
Insulin Resistance
Metabolic syndrome
Body mass index
Biomarkers
Phytotherapy
Food Science
Zdroj: Nutrients
NUTRIENTS(8): 11
Nutrients, Vol 8, Iss 11, p 734 (2016)
Nutrients; Volume 8; Issue 11; Pages: 734
ISSN: 2072-6643
DOI: 10.3390/nu8110734
Popis: Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs.
Databáze: OpenAIRE
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