The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
| Autor: | Mark P.A. Luna-Vargas, Jerry E. Chipuk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Peroxisome membrane Apoptosis Biology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Peroxisomes medicine Animals Humans BCL-2 Gene Family Spotlight neoplasms bcl-2-Associated X Protein Voltage-Dependent Anion Channel 2 Peroxisomal matrix Bcl-2 family Membrane Proteins Cell Biology Peroxisome Mitochondria Cell biology bcl-2 Homologous Antagonist-Killer Protein 030104 developmental biology medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Mitochondrial Membranes Commentary biological phenomena cell phenomena and immunity VDAC2 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.201701187 |
| Popis: | Chipuk and Luna-Vargas discuss Hosoi et al.’s study revealing conserved regulation of mitochondrial and peroxisome membrane permeabilization by the Bcl2 family. Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins. |
| Databáze: | OpenAIRE |
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