An Elevation of Stem Cell Factor in Patients with Hyperthyroid Graves' Disease
| Autor: | Eizaburo Tejima, Yoshiharu Ito, Soshin Onuma, Toru Aizawa, Akira Terao, Takashi Yamada, Akira Kanamori, Yutaka Nakamura, Akira Sato, Yasuhiro Miyahara, Hiromi Ootsuka, Hideki Sakai |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Thyroiditis endocrine system medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Thyroid Gland Stem cell factor Trab Disease Thyrotropin receptor Endocrinology Antithyroid Agents Recurrence Internal medicine Humans Medicine In patient Aged Stem Cell Factor Methimazole biology business.industry Thyroiditis Autoimmune Middle Aged medicine.disease Graves Disease medicine.anatomical_structure Acute Disease Immunology biology.protein Female Bone marrow Antibody business |
| Zdroj: | Thyroid. 8:499-504 |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | Graves' disease is an autoimmune disorder characterized by the presence of antibodies against thyrotropin receptor (TRAb). Stem cell factor (SCF), derived from bone marrow, is known to promote lymphohematopoiesis. To investigate the relation between the alteration in plasma levels of SCF, thyroid hormone status, and TRAb measured by thyrotropin binding inhibition (TBI), 13 untreated, 21 treated, and 4 relapsed hyperthyroid Graves' disease patients, 21 patients with Hashimoto's thyroiditis, 6 patients with subacute thyroiditis, and 11 control subjects were examined. In untreated hyperthyroid Graves' disease patients, serum levels of thyroxine (T4) and triiodothyronine decreased rapidly by methimazole treatment, and TBI decreased progressively, but variably. Simultaneously, the elevated plasma levels of SCF decreased gradually and progressively. The plasma levels of SCF correlated curvilinearly with the serum levels of T4. In 4 patients with relapsed hyperthyroid Graves' disease, TBI was marginally positive in 3 patients and negative in 1, but plasma levels of SCF were elevated significantly in all 4 patients. In patients with subacute thyroiditis and Hashimoto's thyroiditis with or without T4 replacement, plasma levels of SCF did not differ from that of controls. These findings indicate that the elevation of plasma levels of SCF relates to the longstanding thyrotoxic state and that short-term thyrotoxicosis does not significantly affect plasma levels of SCF. It remains to be determined whether the elevation in plasma levels of SCF is induced by excess thyroid hormone, reflecting the hypermetabolic state, or whether the elevation of plasma levels of SCF contributes to stimulation of lymphocytes producing TRAb. |
| Databáze: | OpenAIRE |
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