Clinical Value of Routine Serum Squamous Cell Carcinoma Antigen in Follow-Up of Patients With Early-Stage Cervical Cancer
| Autor: | J.M. Duk, Harry Hollema, Wim J. Sluiter, Henk W.A. de Bruijn, Jan G. Aalders, Martha D. Esajas, Ate G.J. van der Zee, Betty Pras, Klaske A. ten Hoor, Pax H.B. Willemse |
|---|---|
| Přispěvatelé: | Targeted Gynaecologic Oncology (TARGON) |
| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Salvage therapy Disease Gastroenterology Antigen Antigens Neoplasm Internal medicine Biomarkers Tumor RADICAL HYSTERECTOMY Carcinoma medicine Humans Radical Hysterectomy Stage (cooking) Serpins Cervical cancer business.industry UTERINE CERVIX medicine.disease Surgery Radiation therapy stomatognathic diseases Oncology Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Journal of Clinical Oncology, 19(19), 3960-3966. AMER SOC CLINICAL ONCOLOGY |
| ISSN: | 1527-7755 0732-183X |
| Popis: | PURPOSE: To investigate the contribution to recurrence detection and survival of serum squamous cell carcinoma antigen (SCC-ag) analysis in the follow-up of early-stage cervical cancer patients. PATIENTS AND METHODS: Follow-up data were evaluated in patients with early-stage squamous cell cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy with or without radiotherapy. Routine serum SCC-ag determination was performed at each follow-up visit. RESULTS: Recurrent disease occurred in 35 (16%) of 225 patients and was preceded or accompanied by serum SCC-ag elevation 26 times (sensitivity, 74%). In five (14%) of these 35 patients, elevated serum SCC-ag was the first measured clinical indicator. Desite salvage therapy, all five patients died of disease. In the other 31 patients (21 with serum SCC-ag elevation), either symptoms and/or positive signs led to recurrence detection. Median survival time after recurrence was worse (9 months; range, 2 to 112+) for patients with an elevated serum SCC-ag value at recurrence in comparison with patients with normal serum SCC-ag values (20 months; range, 4 to 96; P < .01). In 23 of the 190 patients without recurrences, serum SCC-ag values became falsely elevated. In 16 of these 23 patients, the repeat sample after 6 weeks showed a normal SCC-ag, and in seven patients benign (especially skin) disorders were found. CONCLUSION: Serum SCC-ag analysis results in earlier recurrence detection in a small proportion (14%) of patients but did not contribute to better survival. As long as treatment possibilities for recurrent cervical cancer patients are not improved, serum SCC-ag analysis should not be carried out in routine follow-up. |
| Databáze: | OpenAIRE |
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