Genome of Tetraploid Fish Schizothorax o'connori Provides Insights into Early Re-diploidization and High-Altitude Adaptation
| Autor: | Ruibin Yang, Ding-Ding Fan, Chaowei Zhou, Wang Wanliang, Shilin Zhu, Zeng Benhe, Ming Zou, Shijun Xiao, He Zhou, Yajuan Li, Hong Li, Yu Zou, Yanchao Liu, Liu Fei, Jiaqi Liu, Mou Zhenbo, Di Wang, Liu Haiping |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Transposable element Genomics 02 engineering and technology Biology Genome Article 03 medical and health sciences Polyploid lcsh:Science Transcriptomics Gene Evolutionary Biology Multidisciplinary Natural selection food and beverages Biological Sciences 021001 nanoscience & nanotechnology biology.organism_classification 030104 developmental biology Evolutionary biology lcsh:Q Adaptation 0210 nano-technology Schizothorax |
| Zdroj: | iScience iScience, Vol 23, Iss 9, Pp 101497-(2020) |
| ISSN: | 2589-0042 |
| Popis: | Summary Whole-genome duplications (WGDs) of Schizothoracinae are believed to have played a significant role in speciation and environmental adaptation on the Qinghai-Tibet Plateau (QTP). Here, we present a genome for Schizothorax o'connori, a QTP endemic fish and showed the species as a young tetraploid with a recent WGD later than ∼1.23 mya. We exhibited that massive insertions between duplicated genomes caused by transposon bursts could induce mutagenesis in adjacent sequences and alter the expression of neighboring genes, representing an early re-diploidization process in a polyploid genome after WGD. Meanwhile, we found that many genes involved in DNA repair and folate transport/metabolism experienced natural selection and might contribute to the environmental adaptation of this species. Therefore, the S. o'connori genome could serve as a young tetraploid model for investigations of early re-diploidization in polyploid genomes and offers an invaluable genetic resource for environmental adaptation studies of the endemic fish of the QTP. Graphical Abstract Highlights • Schizothorax o'connori underwent a recent WGD later than ∼1.23 mya • Transposon bursts prompted sequence divergence after duplication • Transposon can induce sequence mutagenesis and regulate gene expression • Many genes in DNA repair and folate transport/metabolism were naturally selected Biological Sciences; Evolutionary Biology; Genomics; Transcriptomics |
| Databáze: | OpenAIRE |
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