Inhibition of experimental mammary carcinoma. Autologous intrasplenic ovarian transplant
| Autor: | Rose Marie Reichle, Michael B. Shimkin, George P. Rosemond, David R. Meranze, Margot Gruenstein, Frederick A. Reichle |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Mammary gland Portal venous system Portacaval shunt Ovary Adenocarcinoma medicine.disease_cause Transplantation Autologous Mammary Glands Animal Internal medicine Benz(a)Anthracenes Medicine Animals skin and connective tissue diseases business.industry Portacaval Shunt Surgical Body Weight Mammary Neoplasms Experimental Estrogens Autotransplantation Surgery Rats medicine.anatomical_structure Endocrinology Liver Cancer research Female business Carcinogenesis Breast carcinoma Spleen Hormone |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 104(2) |
| ISSN: | 0004-0010 |
| Popis: | Intrasplenic ovarian autotransplantation is associated with significant inhibition of 7,12-dimethylbenz (a) anthracene-produced breast carcinoma in the rat. The mechanism of this inhibition may be related to the position of the transplanted ovary within the portal venous system, allowing initial drainage of ovarian venous efflux through the liver. Hepatic alteration of ovarian hormones could result in changes in hormone concentration within the mammary gland, and this may represent the mechanism of inhibition of tumorigenesis. End-to-side portacaval shunt done simultaneously with intrasplenic ovarian transplantation is also associated with significant inhibition of experimental breast carcinoma. The previously observed inhibition of experimental breast carcinoma by end-to-side portacaval shunt alone has been reconfirmed. |
| Databáze: | OpenAIRE |
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