Disposition of intravenous metronidazole in Asian surgical patients
| Autor: | How Sung Lee, Yok Moi Khoo, Ti Ty |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolite Population Pharmacology Gastroenterology chemistry.chemical_compound Anti-Infective Agents Pharmacokinetics Metronidazole Internal medicine medicine Humans Surgical Wound Infection Pharmacology (medical) Trough Concentration education Chromatography High Pressure Liquid Aged Antibacterial agent Volume of distribution education.field_of_study Half-life Liter Middle Aged Infectious Diseases chemistry Injections Intravenous Female Half-Life Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 40:2248-2251 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Steady-state peak and trough concentrations of metronidazole and its metabolites were measured in the sera of 54 surgical patients who were on intravenous metronidazole, 500 mg every 8 h. These patients had no significant renal or hepatic impairment. High-pressure liquid chromatography was used to determine the concentrations of metronidazole and its metabolites. The mean peak and trough metronidazole concentrations were 28.9 +/- 11.0 and 18.0 +/- 9.9 micrograms/ml, respectively. The acid metabolite was not detectable in all the blood specimens. The mean peak concentration of the hydroxy metabolite (MH) was 6.6 +/- 4.3 micrograms/ml, the mean trough concentration of MH was 6.2 +/- 4.2 micrograms/ml, and the MH concentration/metronidazole concentration ratio was 0.4 +/- 0.24. Using a population-based method for the pharmacokinetic analysis and stepwise regression between parameters and covariables (sex, age, and weight), we found that weight showed the highest correlation with the total body clearance (CL). The mean CL was 0.89 +/- 0.3 ml min-1 kg-1 (3.029 liters/h), the mean volume of distribution was 0.73 +/- 0.14 liter/kg, and the mean elimination half-life was 10.6 +/- 4.5 h. For the patients in our study, the CL was lower and the elimination half-life was longer compared with those for healthy volunteers, but the values of these parameters were comparable to those found for hospitalized patients. There was an inverse correlation between age and CL. |
| Databáze: | OpenAIRE |
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