Arterial blood gases and acid-base status of dogs during graded dynamic exercise
| Autor: | D. B. Friedman, Timothy I. Musch, G. A. Ordway, James Stray-Gundersen, G. C. Haidet, T. G. Waldrop |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Physiology Physical Exertion Hyperpnea Physical exercise Body Temperature Dogs Oxygen Consumption Hypocapnia Physiology (medical) Internal medicine Hyperventilation medicine Animals Lactic Acid Acid-Base Equilibrium Pulmonary Gas Exchange Chemistry Hemodynamics VO2 max Metabolic acidosis Arteries Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Oxygen Blood Endocrinology Respiratory alkalosis Anesthesia Lactates Arterial blood medicine.symptom |
| Zdroj: | Journal of Applied Physiology. 61:1914-1919 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1986.61.5.1914 |
| Popis: | The objective of this study was to determine whether arterial PCO2 (PaCO2) decreases or remains unchanged from resting levels during mild to moderate steady-state exercise in the dog. To accomplish this, O2 consumption (VO2) arterial blood gases and acid-base status, arterial lactate concentration ([LA-]a), and rectal temperature (Tr) were measured in 27 chronically instrumented dogs at rest, during different levels of submaximal exercise, and during maximal exercise on a motor-driven treadmill. During mild exercise [35% of maximal O2 consumption (VO2 max)], PaCO2 decreased 5.3 +/- 0.4 Torr and resulted in a respiratory alkalosis (delta pHa = +0.029 +/- 0.005). Arterial PO2 (PaO2) increased 5.9 +/- 1.5 Torr and Tr increased 0.5 +/- 0.1 degree C. As the exercise levels progressed from mild to moderate exercise (64% of VO2 max) the magnitude of the hypocapnia and the resultant respiratory alkalosis remained unchanged as PaCO2 remained 5.9 +/- 0.7 Torr below and delta pHa remained 0.029 +/- 0.008 above resting values. When the exercise work rate was increased to elicit VO2 max (96 +/- 2 ml X kg-1 X min-1) the amount of hypocapnia again remained unchanged from submaximal exercise levels and PaCO2 remained 6.0 +/- 0.6 Torr below resting values; however, this response occurred despite continued increases in Tr (delta Tr = 1.7 +/- 0.1 degree C), significant increases in [LA-]a (delta [LA-]a = 2.5 +/- 0.4), and a resultant metabolic acidosis (delta pHa = -0.031 +/- 0.011). The dog, like other nonhuman vertebrates, responded to mild and moderate steady-state exercise with a significant hyperventilation and respiratory alkalosis.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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