Thyroid peroxidase activity in euthyroid and mild hypothyroid patients with Hashimoto's thyroiditis
| Autor: | Makiko Yamamoto, Kaoru Yoshinaga, Nobuko Kaise, Shintaro Saito, Kazuo Kaise |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Arbitrary unit Thyroid Gland Thyrotropin Stimulation Thyroid peroxidase activity Thyroiditis Basal (phylogenetics) Endocrinology Thyroid peroxidase Internal medicine medicine Humans Euthyroid Aged biology business.industry Thyroiditis Autoimmune Middle Aged medicine.disease Thyroxine Peroxidases biology.protein Triiodothyronine Female Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Metabolism. 28:659-662 |
| ISSN: | 0026-0495 |
| Popis: | Thyroid peroxidase (TPO) activity was measured spectrophotometrically according to Hosoya's guaiacol method. The mean TPO activity in ten patients with Hashimoto's thyroiditis was 19.8 +/- 7.6 (mean +/- SE) in an arbitrary unit, which was not significantly different from the normal value in seven normal thyroid tissues (33.7 +/- 5.4). The ten patients were divided into two groups, euthyroid and mild hypothyroid, on the basis of their basal serum TSH. In the euthyroid group, TPO activity (8.17 +/- 1.3) was significantly less than the normal tissue (p less than 0.01). In the hypothyroid group, TPO activity (27.64 +/- 13.8) was almost similar to the normal tissue. A positive correlation was obtained between TPO activity and serum TSH in ten patients with Hashimoto's thyroiditis (r = 0.85, p less than 0.01). It was concluded that TPO activity is significantly decreased in Hashimoto's thyroiditis even when the thyroid function was still within normal range, but the activity might be restored to normal in hypothyroid patients by the stimulation of elevated TSH. |
| Databáze: | OpenAIRE |
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