High or low temperature extraction, which is more conducive to Triphala against chronic pharyngitis?
| Autor: | Xi-Chuan Wei, Xuan Deng, Fei Ran, Jiao Song, Zhen-Feng Wu, Yu Wang, Li Han, Hao-Zhou Huang, Dingkung Zhang, Junzhi Lin, Ming Qiu, San-Hu Fan, Han Xue |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Chronic pharyngitis Phytochemicals RM1-950 Reflux extraction Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Decompressing inner ebullition 0302 clinical medicine Picrates Animals Tannin Protein Interaction Maps Gallic acid Triphala Pharmacology chemistry.chemical_classification Chromatography Behavior Animal Plant Extracts Biphenyl Compounds Temperature Pharyngitis Catechin General Medicine Chebulic acid 030104 developmental biology Epicatechin gallate chemistry 030220 oncology & carcinogenesis Chronic Disease Cytokines Pharynx Female Therapeutics. Pharmacology Corilagin Ellagic acid |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111787-(2021) |
| ISSN: | 0753-3322 |
| Popis: | Objective: Explore the effects of high-temperature reflux extraction and low-temperature decompressing inner ebullition on Triphala's chemical composition and anti-chronic pharyngitis activity. Methods: The network pharmacology was used to analyze the material basis, targets and pathways of Triphala for chronic pharyngitis. HPLC were used to compare the fingerprint profile and content of components between the two extracts. The antioxidant and anti-chronic pharyngitis activities of the two extracts were compared by DPPH assay and ammonia induced chronic pharyngitis model in rats. Results: The network pharmacology results showed that the active ingredients of Triphala for chronic pharyngitis are epigallocatechin-3-gallate, (+)-catechin, epicatechin, epicatechin gallate, (+)-gallocatechin, quercetin, luteolin, leucodelphinidin and other flavonoids; phenolic acids such as gallic acid and ellagic acid; alkaloids such as ellipticine, cheilanthifoline; hydrolyzed tannins such as corilagin and chebulic acid. The high-temperature reflux extract and the low-temperature decompressing inner ebullition extract have extremely significant differences in the fingerprint profile. Among them, the content of gallic acid, ellagic acid, chebulic acid, catechin, epicatechin, corilagin, quercetin, and epicatechin gallate in the reflux extract is 1.1–5.3 times as much as decompressing inner ebullition extract. The free radical scavenging ability of reflux extract is significantly stronger than that of decompression extract (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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