The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas

Autor: Angélica Martínez-Hernández, Guadalupe Salas-Martínez, Eva Gabriela Salas-Bautista, Elaheh Mirzaeicheshmeh, Francisco Loeza-Becerra, Aleksandar Kostic, Augusto Rojas-Martinez, Carlos Galaviz-Hernández, Blanca Patricia Lazalde-Ramos, Austin W. Reynolds, Paulina Baca, José Sánchez-Corona, Humberto García-Ortiz, Antonio Blanchet, Héctor Rangel-Villalobos, Jazmín Ramos-Madrigal, José Concepción Jiménez-López, Elvia Mendoza-Caamal, Silvia Esperanza Flores-Martínez, Rafael Velázquez-Cruz, Juan Luis Jiménez-Ruíz, Marlen Flores-Huacuja, Guadalupe León-Reyes, Federico Centeno-Cruz, María Del Carmen Abrahantes-Pérez, Mirna Edith Morales-Marín, Lorena Orozco, Rocio Ortiz-Lopez, Emilio J. Cordova, Miguel Ángel Cid-Soto, Raúl Mojica-Espinosa, Yolanda Saldaña-Alvarez, Deborah A. Bolnick, Francisco Barajas-Olmos, Martha Sosa-Macías, Meradeth Snow, Cecilia Contreras-Cubas, Alejandra Guadalupe García-Zapién, Isabel Cicerón-Arellano, Federico Sánchez-Quinto
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
García-Ortiz, H, Barajas-Olmos, F, Contreras-Cubas, C, Cid-Soto, M Á, Córdova, E J, Centeno-Cruz, F, Mendoza-Caamal, E, Cicerón-Arellano, I, Flores-Huacuja, M, Baca, P, Bolnick, D A, Snow, M, Flores-Martínez, S E, Ortiz-Lopez, R, Reynolds, A W, Blanchet, A, Morales-Marín, M, Velázquez-Cruz, R, Kostic, A D, Galaviz-Hernández, C, García-Zapién, A G, Jiménez-López, J C, León-Reyes, G, Salas-Bautista, E G, Lazalde-Ramos, B P, Jiménez-Ruíz, J L, Salas-Martínez, G, Ramos-Madrigal, J, Mirzaeicheshmeh, E, Saldaña-Alvarez, Y, del Carmen Abrahantes-Pérez, M, Loeza-Becerra, F, Mojica-Espinosa, R, Sánchez-Quinto, F, Rangel-Villalobos, H, Sosa-Macías, M, Sánchez-Corona, J, Rojas-Martinez, A, Martínez-Hernández, A & Orozco, L 2021, ' The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas ', Nature Communications, vol. 12, 5942 . https://doi.org/10.1038/s41467-021-26188-w
Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26188-w
Popis: The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far.
Indigenous populations, including in those in Mexico are underrepresented in genetic studies. Here, the authors perform a population genetics study of indigenous peoples in Mexico to explore demographic histories of the region in the context of geography and cultural influences.
Databáze: OpenAIRE
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