Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress
| Autor: | Jozef Nakonechnyy, Michal Kups, Marzena Kamieniczna, Maciej Kurpisz, V. Chopyak, Kamil Gill, Andrij Nakonechnyy, Tomasz Wozniak, Monika Fraczek, Lukasz Wojnar, Anna Havrylyuk, Małgorzata Piasecka |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Physiology medicine.disease_cause Antioxidants Male infertility lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Malondialdehyde lcsh:QH301-705.5 Spectroscopy Epididymis 030219 obstetrics & reproductive medicine accessory glands Prostate General Medicine Spermatozoa Computer Science Applications medicine.anatomical_structure 030220 oncology & carcinogenesis Infertility Adult Context (language use) Article Catalysis Inorganic Chemistry 03 medical and health sciences Semen quality Young Adult medicine Humans Physical and Theoretical Chemistry Molecular Biology Infertility Male Genitourinary system business.industry Organic Chemistry medicine.disease Semen Analysis Oxidative Stress genital heat stress lcsh:Biology (General) lcsh:QD1-999 chemistry business Oxidative stress Biomarkers Heat-Shock Response |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 17 International Journal of Molecular Sciences, Vol 21, Iss 6427, p 6427 (2020) |
| ISSN: | 1422-0067 |
| Popis: | The pathophysiological mechanisms responsible for male subfertility/infertility caused by or complicated by genital heat stress remains unclear in many respects. Because seminal plasma creates the environment for the proper functioning of spermatozoa, in this study, we verified the associations among standard spermiograms, seminal biochemical parameters (neutral alpha-glucosidase, fructose, and citric acid) and oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) in distinct entities associated with male infertility with and without long-time exposure to local hyperthermia. We demonstrated that men exposed to prolonged environmental or clinically recognized local heat stress in adulthood may suffer from dysregulation of seminal antioxidant components, which can be directly associated with epididymal and prostate function. The comparative analysis of the studied parameters showed numerous correlations among all biochemical parameters (particularly neutral alpha-glucosidase) with low standard semen quality in almost all the investigated infertile groups. In light of the data obtained in this originally designed study, we conclude that more attention should be paid to the epididymis and accessory gland function in subfertile and infertile men exposed to genital heat stress, especially in the context of novel treatment algorithms (targeted therapies). |
| Databáze: | OpenAIRE |
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