Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
| Autor: | Sílvia Orgué, Xavier Verdaguer, Antoni Riera, Ernest Salomó |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
ligand design
Ethyl acetate chemistry.chemical_element Enantiòmers enamides 010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound Organic chemistry Iridium Enantioselective catalysis Hidrogenació 010405 organic chemistry Communication Asymmetric hydrogenation Enantioselective synthesis General Chemistry General Medicine iridium Environmentally friendly Communications P ligands 0104 chemical sciences Catàlisi asimètrica Asymmetric Hydrogenation chemistry Enantiomers Methanol Hydrogenation Selectivity |
| Zdroj: | Angewandte Chemie (International Ed. in English) Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | The MaxPHOX–Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α‐ and β‐tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal‐coordinating groups. In the present system, selectivity was pressure‐dependent: In most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity. |
| Databáze: | OpenAIRE |
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