Lymphopenia in critically ill COVID‐19 patients: A predictor factor of severity and mortality

Autor: Ahmed Rhassane El Adib, Brahim Admou, Amra Ziadi, S. Younous, Raja Hazime, Abdenasser M. Samkaoui, Abdelhamid Hachimi, Imane Brahim, Fouzia Douirek, Youssef Zarrouki
Rok vydání: 2020
Předmět:
Lymphocyte
Clinical Biochemistry
Blood Donors
intensive care unit
law.invention
COVID-19 Testing
law
Thrombophilia
Medicine
Letter to the Editor
Venous Thromboembolism
Hematology
General Medicine
Intensive care unit
C-Reactive Protein
medicine.anatomical_structure
Cytokines
Blood Coagulation Tests
Coronavirus Infections
Cytokine Release Syndrome
Risk
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
MEDLINE
lymphocyte
Letter to the Editors
Fibrin Fibrinogen Degradation Products
Betacoronavirus
Meta-Analysis as Topic
COVID‐19
Lymphopenia
Internal medicine
Humans
Pandemics
lymphocyte subset
Biochemistry
medical
Clinical Laboratory Techniques
SARS-CoV-2
business.industry
Critically ill
Biochemistry (medical)
Anticoagulants
COVID-19
Disseminated Intravascular Coagulation
Early Diagnosis
Ferritins
Critical illness
business
Biomarkers
Zdroj: International Journal of Laboratory Hematology
ISSN: 1751-553X
1751-5521
DOI: 10.1111/ijlh.13351
Popis: COVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL-6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID-19 patients. Elevated D-Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life-threatening disseminated intravascular coagulation (DIC), which necessitates continuous vigilance and prompt intervention. So, COVID-19 infected patients, whether hospitalized or ambulatory, are at high risk for venous thromboembolism, and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also highlighted.
Databáze: OpenAIRE
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