Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus–CSF nexus

Autor: Edward G. Stopa, Conrad E. Johanson, Andrew Baird, Hari Shanker Sharma
Rok vydání: 2010
Předmět:
Hippocampus
Ischemia
Medicine & Public Health
Pharmacology/Toxicology
Intracranial pressure
Psychiatry
Traumatic brain injury models
biology
Neurogenesis
Blood-CSF barrier permeability
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Leukocyte traffic
Basic Neurosciences
Genetics and Immunology - Review Article
Cerebrospinal formation and drainage
Choroid plexus
Ependyma
Hydrocephalus
Neurotrophin
Subventricular zone
Traumatic brain injury
Midline Thalamic Nuclei
CSF dynamics
Clinical Neurology
Neuroprotection
Blood–CSF barrier permeability
CSF homeostasis
medicine
Animals
Humans
Dentate gyrus
Biological Psychiatry
Periventricular lesions
business.industry
Neuropeptides
Neurosciences
Recovery of Function
medicine.disease
Disease Models
Animal
nervous system
Brain Injuries
Choroid Plexus
biology.protein
Neurology (clinical)
business
Neuroscience
Zdroj: Journal of Neural Transmission
Johanson, Conrad; Stopa, Edward; Baird, Andrew; & Sharma, Hari. (2011). Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus–CSF nexus. Journal of Neural Transmission: Basic Neurosciences, Genetics and Immunology, Movement disorders, Dementias, Biological Psychiatry, Biological Child and Adolescent Psychiatry, 118(1), pp 115-133. doi: 10.1007/s00702-010-0498-0. Retrieved from: http://www.escholarship.org/uc/item/1ts4426f
Johanson, C; Stopa, E; Baird, A; & Sharma, H. (2011). Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus. JOURNAL OF NEURAL TRANSMISSION, 118(1), 115-133. doi: 10.1007/s00702-010-0498-0. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/934253pb
ISSN: 1435-1463
0300-9564
DOI: 10.1007/s00702-010-0498-0
Popis: In traumatic brain injury (TBI), severe disruptions occur in the choroid plexus (CP)-cerebrospinal fluid (CSF) nexus that destabilize the nearby hippocampal and subventricular neurogenic regions. Following invasive and non-invasive injuries to cortex, several adverse sequelae harm the brain interior: (i) structural damage to CP epithelium that opens the blood-CSF barrier (BCSFB) to protein, (ii) altered CSF dynamics and intracranial pressure (ICP), (iii) augmentation of leukocyte traffic across CP into the CSF-brain, (iv) reduction in CSF sink action and clearance of debris from ventricles, and (v) less efficient provision of micronutritional and hormonal support for the CNS. However, gradual post-TBI restitution of the injured CP epithelium and ependyma, and CSF homeostatic mechanisms, help to restore subventricular/subgranular neurogenesis and the cognitive abilities diminished by CNS damage. Recovery from TBI is facilitated by upregulated choroidal/ependymal growth factors and neurotrophins, and their secretion into ventricular CSF. There, by an endocrine-like mechanism, CSF bulk flow convects the neuropeptides to target cells in injured cortex for aiding repair processes; and to neurogenic niches for enhancing conversion of stem cells to new neurons. In the recovery from TBI and associated ischemia, the modulating neuropeptides include FGF2, EGF, VEGF, NGF, IGF, GDNF, BDNF, and PACAP. Homeostatic correction of TBI-induced neuropathology can be accelerated or amplified by exogenously boosting the CSF concentration of these growth factors and neurotrophins. Such intraventricular supplementation via the CSF route promotes neural restoration through enhanced neurogenesis, angiogenesis, and neuroprotective effects. CSF translational research presents opportunities that involve CP and ependymal manipulations to expedite recovery from TBI.
Databáze: OpenAIRE
Externí odkaz: