Multisystem Inflammatory Syndrome in Children Admitted to a Tertiary Pediatric Intensive Care Unit
| Autor: | Emrah Gün, Ergin Çiftçi, Anar Gurbanov, Tayfun Uçar, Nazmiye Türker, Ali Genco Gençay, Mehmet G. Ramoğlu, Gül Arga, Ercan Tutar, Burak Balaban, Edin Botan, Selen Karagözlü, Tanıl Kendirli, Halil Özdemir |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatric intensive care unit
Abdominal pain Pediatrics medicine.medical_specialty business.industry medicine.medical_treatment Acute kidney injury Critical Care and Intensive Care Medicine medicine.disease Rash Interquartile range Intensive care Pediatrics Perinatology and Child Health medicine Renal replacement therapy medicine.symptom Headaches business |
| Zdroj: | J Pediatr Intensive Care |
| ISSN: | 2146-4626 2146-4618 |
| DOI: | 10.1055/s-0041-1733943 |
| Popis: | Background Multisystem inflammatory syndrome in children (MIS-C) is characterized by persistent fever, abdominal pain, vomiting, diarrhea, rash, conjunctivitis, headaches, and mucocutaneous manifestations and it can cause circulatory dysfunction, resulting in hypotension, shock, and end-organ injury in the heart and other organs and possibly death. In this study, we aimed to analyze the clinical spectrum, treatment options and outcomes of children with MIS-C who were admitted to our pediatric intensive care (PICU). Materials and Methods Clinical and laboratory findings and treatment of the patients admitted to the PICU with MIS-C between April 2020 and January 2021 were recorded, and their outcomes were evaluated. Results Nineteen patients with a median age of 12.5 years (interquartile range (IQR): 5.8–14.0 years) were admitted. Eleven (57.8%) were males. The most frequent clinical and laboratory features were fever (100%), abdominal pain (94.7%), rash (63.1%), headache (68.4%), diarrhea (47.3%), seizure (10.5%), cardiac dysfunction (52.6%), acute kidney injury (26.3%), lymphopenia (84.2%), and thrombocytopenia (36.8%). However, 8 patients needed mechanical respiratory support, 11 patients needed inotropes, 2 patients needed plasma exchange, and 1 patient needed continuous renal replacement therapy. All patients received corticosteroids, 17 patients (89.2%) received intravenous immunoglobulin, 2 patients received anakinra, 10 patients received acetylsalicylic acid, and 6 patients received enoxaparin. Median PICU length of stay was 3 days (IQR: 2–5) and only one patient died. Conclusion In conclusion, MIS-C may present with a variety of clinical manifestations, and it can lead to life-threatening critical illness. Most children need intensive care and the response to immunomodulation is usually favorable. |
| Databáze: | OpenAIRE |
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