Infections Caused by HRSV A ON1 Are Predominant among Hospitalized Infants with Bronchiolitis in São Paulo City
| Autor: | Marina Baquerizo Martinez, Daniele Oliveira, Edison Luiz Durigon, Sandra Elisabete Vieira, Milena de Paulis, Luciano M. Thomazelli, Angela Esposito Ferronato |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Genotype Article Subject lcsh:Medicine Respiratory Syncytial Virus Infections Real-Time Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Virus law.invention 03 medical and health sciences 0302 clinical medicine law 030225 pediatrics Epidemiology medicine Bronchiolitis Viral Humans Respiratory system General Immunology and Microbiology business.industry lcsh:R Infant Newborn Infant General Medicine SÃO PAULO medicine.disease Intensive care unit Hospitalization 030104 developmental biology Bronchiolitis Respiratory Syncytial Virus Human Respiratory virus Female business Nasopharyngeal secretion Brazil Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2017 (2017) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Human respiratory syncytial virus is the main cause of respiratory infections in infants. Several HRSV genotypes have been described. Goals. To describe the main genotypes that caused infections in São Paulo (2013–2015) and to analyze their clinical/epidemiological features. Methods. 94 infants (0–6 months) with bronchiolitis were studied. Clinical/epidemiological information was collected; a search for 16 viruses in nasopharyngeal secretion (PCR-real-time and conventional, sequencing, and phylogenetic analyses) was performed. Results. The mean age was 2.4 m; 48% were male. The mean length of hospital stay was 4.4 d (14% in the Intensive Care Unit). The positive rate of respiratory virus was 98.9%; 73 cases (77.6%) were HRSV (76,7% HRSVA). HRSVA formed three clusters: ON1 (n=34), NA1 (n=1), and NA2 (n=4). All HRSVB were found to cluster in the BA genotype (BA9-n=10; BA10-n=3). Clinical analyses showed no significant differences between the genotype AON1 and other genotypes. Conclusion. This study showed a high rate of HRSV detection in bronchiolitis. HRSVA ON1, which has recently been described in other countries and has not been identified in previous studies in the southeast region of Brazil, was predominant. The clinical characteristics of the infants that were infected with AON1 were similar to infants with infections by other genotypes. |
| Databáze: | OpenAIRE |
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