The degree of overlap between the follicular dendritic cell meshwork and tumor cells in mantle cell lymphoma is associated with prognosis
| Autor: | Yuan-yuan Zheng, W H Hou, Jian-lan Xie, Yanlin Zhang, Ping Wei, Xiao-ge Zhou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Tumor cells Lymphoma Mantle-Cell Risk Assessment Pathology and Forensic Medicine 03 medical and health sciences Clinical prognosis 0302 clinical medicine hemic and lymphatic diseases Mitotic Index Medicine Humans In Situ Hybridization Fluorescence Retrospective Studies Follicular dendritic cells biology business.industry Proportional hazards model Lymphoma Non-Hodgkin Cell Biology Middle Aged medicine.disease Prognosis Immunohistochemistry Lymphoma Survival Rate 030104 developmental biology Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 biology.protein Mantle cell lymphoma Female business Dendritic Cells Follicular |
| Zdroj: | Pathology, research and practice. 214(4) |
| ISSN: | 1618-0631 |
| Popis: | This study concerning mantle cell lymphoma (MCL) investigated retrospectively an association between patient prognosis and the percentage of the total number of lymphoma cells found in the follicular dendritic cell (FDC) meshwork, that is, the degree of overlap of lymphoma cells. Two hundred and nine MCL patients were apportioned to grades I-III, in which the CD21-positive FDC meshwork covered ≤50%, 51%-89%, and ≥90% of the tumor area, respectively. Significant differences among the grades (all, P 0.01) were found in the following: duration of disease (from onset of clinical manifestation to diagnosis); clinical staging; extranodal involvement (non-lymphoid organs); histological subtype; and Ki-67 proliferation index (PI). After removing the aggressive variants, the overall survival rates of grade I (n = 92) and II (n = 57) patients were similar. The overall survival rates of grade III (n = 46) patients differed from that of grade I + II patients (P 0.01). The grades negatively correlated with the Ki-67 PI value (r = -0.234, P = 0.001). At each grade the OSR of patients with Ki-67 PI ≤30% was similar to that of patients with Ki-6730%. In the Ki-67 PI ≤30% group, the OSRs of the patients differed significantly among the grades. In the Ki-6730% group the OSRs of the grades were similar. The results of multivariate Cox regression analysis showed that the degree of overlap, age and Ki-67 PI was the independent prognostic factors of the OSRs of MCL patients. Our data suggests that MCL patients in whom there was a high degree of overlap between the FDC meshwork and tumor area have a better clinical prognosis. The degree of overlap correlates well with the Ki-67 PI, which can be used to predict the prognosis of patients. |
| Databáze: | OpenAIRE |
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