Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
| Autor: | Eliana Noelia Alonso, Agustina Roldan-Deamicis, Belén Brie, Gabriela Andrea Balogh, Diego Aguilera Braico |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Maitake Pro4X Cancer Research medicine.medical_treatment PREVENCION DE ENFERMEDADES medicine.disease_cause Immune tolerance Metastasis Mice Breast cancer 0302 clinical medicine CANCER DE MAMA Original Research Cancer Biology Neovascularization Pathologic cancer prevention CARCINOGENESIS purl.org/becyt/ford/3.1 [https] Bioquímica y Biología Molecular Gene Expression Regulation Neoplastic Medicina Básica Cell Transformation Neoplastic Phenotype Oncology 030220 oncology & carcinogenesis Female purl.org/becyt/ford/3 [https] carcinogenesis Cancer Prevention CIENCIAS MÉDICAS Y DE LA SALUD Antineoplastic Agents Breast Neoplasms Necrosis 03 medical and health sciences Immune system Cell Line Tumor Breast Cancer medicine Animals Radiology Nuclear Medicine and imaging Mortality Biological Products business.industry Cancer Immunotherapy medicine.disease Xenograft Model Antitumor Assays Disease Models Animal 030104 developmental biology Cancer cell Immunology Cancer research business Carcinogenesis Grifola |
| Zdroj: | Cancer Medicine. 2016, 5(9):2427–2441 Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Cancer Medicine |
| Popis: | The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties. D-Fraction, an extract of Maitake (from the edible Grifola frondosa mushroom), rich in β-glucans, exert notable effects in the immune system. Until now, some published articles suggest that Maitake D-Fraction could have anti-tumoral activity, prevent oncogenesis and metastasis in some tumor types. However, there are no clear data about Maitake D-Fraction action on breast cancer prevention and its exact molecular mechanisms are not yet elucidated. The experiments were performed employing 25 female BALBc mice that were treated with and without Maitake D-Fraction Pro4X or Maitake Standard for 15 days by daily intraperitoneal injection. After treatment period, all mice were implanted with murine tumor cells LM3 to induce mammary tumorigenesis. Animals were checked weekly and killed after 46 days of LM3 transplant; percentage of cancer prevention, rate of tumor growing, and overall survival were determined. Under dissection, the internal organs were evaluated histologically and genetically by RT-PCR. We found that 5 mg/kg per day of Maitake D-Fraction Pro4X, administered dairy during 15 days to BALBc mice was able to block more than 60% breast cancer development. However, Maitake Standard prevents oncogenesis in 26% to respect control. In this work, we found that Maitake D-Fraction Pro4X, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival. Fil: Roldan Deamicis, Agustina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Alonso, Eliana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina Fil: Brie, Belen. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Aguilera Braico, Diego Máximo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina |
| Databáze: | OpenAIRE |
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