Neonatal coagulopathy in preterm, small-for-gestational-age infants
| Autor: | Simon Hannam, Anne Greenough, Rebecca J. Edwards, Christoph Lees |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Fetal Hypoxia Ultrasonography Prenatal Umbilical Arteries medicine.artery Infant Mortality medicine Coagulopathy Humans reproductive and urinary physiology business.industry Obstetrics Case-control study Infant Newborn Umbilical artery Ultrasonography Doppler Hypoxia (medical) Blood Coagulation Disorders medicine.disease Prognosis female genital diseases and pregnancy complications Surgery Liver Recien nacido Case-Control Studies Pulsatile Flow Pediatrics Perinatology and Child Health Infant Small for Gestational Age Gestation Small for gestational age medicine.symptom Liver dysfunction business Infant Premature Developmental Biology |
| Zdroj: | Biology of the neonate. 83(3) |
| ISSN: | 0006-3126 |
| Popis: | Our aim was to determine if antenatal hypoxia was associated with liver dysfunction and coagulation abnormalities in small-for-gestational-age (SGA) infants. Sixteen SGA infants, median gestational age 30 (range 26–32) weeks, who consecutively had had umbilical artery Doppler studies in the week before delivery, were compared to appropriate-for-gestational-age (AGA) controls, who were each matched to an SGA infant for gestational age. The median international normalised ratio (INR) was significantly higher (1.9 vs. 1.3, p < 0.001) and the neutrophil (p = 0.003) and platelet counts (p < 0.001), alkaline phosphatase (p < 0.001) and albumin (p < 0.02) levels significantly lower in the SGA compared to the AGA group. The umbilical artery pulsatility index (PI) was elevated, indicating antenatal hypoxia, in all but 1 of the SGA infants. Multiple linear regression analysis demonstrated that the INR was significantly related to the umbilical artery PI independent of the other variables (p = 0.0002, R2 = 0.71). These results suggest that the coagulopathy seen in preterm SGA infants might at least be partially explained by antenatal hypoxia affecting the liver and hence vitamin K-dependent coagulation. |
| Databáze: | OpenAIRE |
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