| Autor: |
Pande, Shreerang, Mitra, Debarshi, Chatterji, Apratim |
| Rok vydání: |
2023 |
| Předmět: |
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| DOI: |
10.48550/arxiv.2304.02275 |
| Popis: |
Recent experiments have been able to visualise chromosome organization in fast-growing E.coli cells. However, the mechanism underlying the spatio-temporal organization remains poorly understood. We propose that the DNA adopts a specific polymer topology as it goes through its cell cycle. We establish that the emergent entropic forces between polymer segments of the DNA-polymer with modified topology, leads to chromosome organization as seen in-vivo. We employ computer simulations of a replicating bead spring model of a polymer in a cylinder to investigate the problem. Our simulation of the overlapping cell cycles not only show successful segregation, but also reproduces the evolution of the spatial organization of the chromosomes as observed in experiments. This manuscript in addition to our previous work on slowly growing bacterial cells, shows that our topology-based model can explain the organization of chromosomes in all growth conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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