Patients with higher vitamin D levels show stronger improvement of self-reported depressive symptoms in psychogeriatric day-care setting
| Autor: | Jürgen Deckert, Stefan Unterecker, Maike Scherf-Clavel, Christine Daniels, Alexandra Herr, Linda D. Zech, Michael Schwab |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anti-depressive treatment
medicine.medical_specialty Neurology Geriatric Psychiatry 030209 endocrinology & metabolism vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine ddc:610 Prospective Studies Vitamin D Prospective cohort study Vitamin D deficiency Biological Psychiatry Depression (differential diagnoses) Aged business.industry Depression Psychiatry and Preclinical Psychiatric Studies - Original Article Psycho-geriatrics medicine.disease Psychiatry and Mental health Quality of Life Geriatric Depression Scale Neurology (clinical) Self Report business Hormone |
| Zdroj: | Journal of Neural Transmission |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Depression is a common psychiatric disorder among geriatric patients that decreases the quality of life and increases morbidity and mortality. Vitamin D as a neuro-steroid hormone might play a role in the onset and treatment of depression. In the present study, the association between depressive symptoms and vitamin D concentration in serum was evaluated. 140 patients of a psychogeriatric day-care unit were included. The geriatric depression scale (GDS) and the Hamilton depression rating scale (HDRS) were assessed at the beginning and end of treatment, GDS scores additionally 6 weeks after discharge from the day-care unit. Vitamin D levels were measured at the beginning of the treatment, routinely. Patients with levels below 30 µg/L were treated with 1000 IU vitamin D per day. There was no association between the severity of depressive symptoms and the concentration of vitamin D at the beginning of the treatment. Patients with higher vitamin D levels showed a stronger decline of depressive symptoms measured by the GDS during their stay in the day-care unit. We provide evidence that vitamin D serum levels might influence antidepressant therapy response in a geriatric population. Prospective studies are necessary to determine which patients may profit from add-on vitamin D therapy. |
| Databáze: | OpenAIRE |
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