Metabolism of formate in the rat
| Autor: | M. Palese, Thomas R. Tephly |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Time Factors Formates education Folic Acid Deficiency Toxicology Formate oxidation chemistry.chemical_compound Folic Acid In vivo Animals Organic chemistry Formate Amitrole Ethanol biology Proteins Metabolism Carbon Dioxide Catalase Pollution Rats Liver Peroxidases chemistry Biochemistry Methanol poisoning Alternative complement pathway biology.protein Oxidation-Reduction |
| Zdroj: | Journal of Toxicology and Environmental Health. 1:13-24 |
| ISSN: | 0098-4108 |
| DOI: | 10.1080/15287397509529305 |
| Popis: | Formate oxidation in the rat in vivo is not altered by catalase inhibition with 3‐amino‐i,2,4‐triazole (A T) or by ethanol. However, the oxidation of formate in rats with folate deficiency is markedly reduced. These results suggest that, in the untreated rat, formate is oxidized through the one‐carbon pool. However, in rats with folate deficiency, A T and ethanol did produce an inhibition of formate oxidation, results that suggest the catalase‐peroxidative system may serve as an alternative pathway for formate oxidation. The importance of these data in studies on methanol poisoning is discussed. |
| Databáze: | OpenAIRE |
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