Functional Bioinorganic Hybrids from Enzymes and Luminescent Silicon-Based Nanoparticles
| Autor: | Xiyu Zhang, Regina Sinelnikov, Christopher Jay T. Robidillo, Angelique Faramus, Jonathan G. C. Veinot, Muhammad Amirul Islam, Job Boekhoven, Maryam Aghajamali |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Silicon
Luminescence Hydrosilylation chemistry.chemical_element Nanoparticle Biosensing Techniques 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound Microscopy Electron Transmission Spectroscopy Fourier Transform Infrared Electrochemistry General Materials Science Spectroscopy Ethylene oxide Chemistry Bioinorganic chemistry Surfaces and Interfaces 021001 nanoscience & nanotechnology Condensed Matter Physics Combinatorial chemistry Enzymes 0104 chemical sciences Nanoparticles 0210 nano-technology Hybrid material |
| Zdroj: | Langmuir. 34:6556-6569 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.8b01119 |
| Popis: | This study reports the preparation of functional bioinorganic hybrid materials exhibiting catalytic activity and photoluminescent properties arising from the combination of enzymes and freestanding silicon-based nanoparticles. The hybrid materials reported herein have potential applications in biological sensing/imaging and theranostics, as they combine long-lived silicon-based nanoparticle photoluminescence with substrate-specific enzymatic activity. Thermal hydrosilylation of undecenoic acid and alkene-terminated poly(ethylene oxide) with hydride-terminated silicon nanocrystals afforded nanoparticles functionalized with a mixed surface made up of carboxylic acid and poly(ethylene oxide) moieties. These silicon-based nanoparticles were subsequently conjugated with prototypical enzymes through the carbodiimide-mediated amide coupling reaction in order to form bioinorganic hybrids that display solubility and photostability in phosphate buffer, photoluminescence (λmax = 630 nm), and enzymatic activity. They... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|