Correlation of iris collagen and in-vivo anterior segment structures in patients in different stages of chronic primary angle-closure in both eyes

Autor: Hailiu Chen, Zhonghao Wang, Jingjing Huang, Chuchen Chung, Jialiu Lin, Miaomiao Dai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Iridectomy
medicine.medical_specialty
genetic structures
medicine.medical_treatment
Gonioscopy
Iris
Trabeculectomy
primary angle closure
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Anterior segment optical coherence tomography
Optical coherence tomography
Chronic primary angle closure glaucoma
lcsh:Ophthalmology
Anterior Eye Segment
In vivo
Ophthalmology
Humans
Medicine
In patient
Iris (anatomy)
Sirius Red
Intraocular Pressure
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Middle Aged
eye diseases
Cross-Sectional Studies
medicine.anatomical_structure
chemistry
lcsh:RE1-994
Chronic Disease
030221 ophthalmology & optometry
Original Article
Female
Collagen
sense organs
Glaucoma
Angle-Closure
business
iris collagen
Tomography
Optical Coherence
030217 neurology & neurosurgery
Zdroj: Indian Journal of Ophthalmology, Vol 67, Iss 10, Pp 1638-1644 (2019)
Indian Journal of Ophthalmology
ISSN: 1998-3689
0301-4738
Popis: Purpose: To compare the density of iris collagen and anterior segment parameters in eyes with chronic primary angle closure glaucoma (CPACG) and their fellow eyes with confirmed or suspected primary angle closure (PAC/PACS). Methods: Nineteen patients with CPACG in one eye and PAC/PACS in the fellow eye requiring trabeculectomy in the CPACG eye and iridectomy in the fellow eye were recruited. Anterior segment optical coherence tomography (AS-OCT) measurements were conducted under light and dark conditions. Iris specimens, obtained by iridectomy/trabeculectomy, were analyzed by sirius red polarization for quantifying type I/III collagen density. AS-OCT parameters and type I/III collagen densities were compared between the two eyes. Results: The iris curvatures were flatter in CPACG eyes in light and dark conditions (P < 0.05). The iris areas in light condition and iris thicknesses in dark condition were smaller in CPACG eyes (P < 0.05). The density of collagen type I in CPACG eyes was lower (P = 0.048). The light-to-dark changes in CPACG eyes and PAC/PACS eyes, respectively, were −0.679 ± 0.701 and −1.627 ± 0.802 mm for pupil diameters, and 0.069 ± 0.113 and 0.258 ± 0.157 mm2 for iris areas, which differed significantly (P < 0.001). With the decrease of type I collagen, anterior chamber width increased and iris areas decreased in dark condition. Conclusion: Dynamic changes in pupil diameter and iris areas differed significantly between CPACG eyes and their fellow PAC/PACS eyes. Decreased type I collagen density in iris tissue was associated with decreased iris area and increased anterior chamber width, which may contribute to disease progression.
Databáze: OpenAIRE
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