Mesenchymal stem/stromal cells in post-menopausal endometrium
| Autor: | Amy Cheong, Kjiana Elkje Schwab, Daniela Ulrich, Anna Rosamilia, James A. Deane, Ker Sin Tan, Caroline E. Gargett |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Stromal cell medicine.drug_class Population CD34 Estrogen receptor Endometrium Andrology Medicine Humans Cell Lineage education Cells Cultured Aged education.field_of_study business.industry Rehabilitation Mesenchymal stem cell Estrogen Replacement Therapy Obstetrics and Gynecology Cell Differentiation Mesenchymal Stem Cells Middle Aged Postmenopause medicine.anatomical_structure Reproductive Medicine Estrogen Female Stem cell Stromal Cells business |
| Zdroj: | Human reproduction (Oxford, England). 29(9) |
| ISSN: | 1460-2350 |
| Popis: | STUDY QUESTION Does post-menopausal endometrium contain mesenchymal stem/stromal cells (MSC) that have adult stem cell properties and can be prospectively isolated from a biopsy? SUMMARY ANSWER Perivascular W5C5(+) cells isolated from post-menopausal endometrial biopsies displayed characteristic MSC properties of clonogenicity, multipotency and surface phenotype irrespective of whether the women were or were not pre-treated with estrogen to regenerate the endometrium. WHAT IS KNOWN ALREADY Recently MSCs have been identified in human premenopausal endometrium, and can be prospectively isolated using a single marker, W5C5/SUSD2. STUDY DESIGN, SIZE, DURATION Endometrial tissue of both the functional and basal layers, from 17 premenopausal (pre-MP) women, 19 post-menopausal (post-MP) women without hormonal treatment and 15 post-menopausal women on estrogen replacement therapy (post-MP+ E2), was collected through a prospective phase IV clinical trial over 2 years. PARTICIPANTS/MATERIALS, SETTING, METHODS Post-menopausal women |
| Databáze: | OpenAIRE |
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