The relative contribution of α‐ and β‐adrenergic sweating during heat exposure and the influence of sex and training status

Autor:	Narihiko Kondo, Tatsuro Amano, Yoshimitsu Inoue, Naoto Fujii, Takeshi Nishiyasu, Glen P. Kenny
Rok vydání:	2020
Předmět:	Atropine Male 0301 basic medicine Agonist medicine.medical_specialty Hot Temperature medicine.drug_class Adrenergic Sweating Muscarinic Antagonists Dermatology Muscarinic Agonists Biochemistry Phenylephrine Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Sex Factors 0302 clinical medicine Internal medicine Muscarinic acetylcholine receptor medicine Humans Albuterol Adrenergic beta-2 Receptor Agonists Molecular Biology integumentary system business.industry Pilocarpine Antagonist Iontophoresis Thermoregulation Forearm 030104 developmental biology Endocrinology Salbutamol Female Adrenergic alpha-1 Receptor Agonists business Physical Conditioning Human medicine.drug
Zdroj:	Experimental Dermatology. 29:1216-1224
ISSN:	1600-0625 0906-6705
DOI:	10.1111/exd.14208
Popis:	While human eccrine sweat glands respond to adrenergic agonists, there remains a paucity of information on the factors modulating this response. Thus, we assessed the relative contribution of α- and β-adrenergic sweating during a heat exposure and as a function of individual factors of sex and training status. α- and β-adrenergic sweating was assessed in forty-eight healthy young men (n = 35) and women (n = 13) including endurance-trained (n = 12) and untrained men (n = 12) under non-heat exposure (temperate, 25°C; n = 17) and heat exposure (hot, 35°C; n = 48) conditions using transdermal iontophoresis of phenylephrine (α-adrenergic agonist) and salbutamol (β-adrenergic agonist) on the ventral forearm, respectively. Adrenergic sweating was also measured after iontophoretic administration of atropine (muscarinic receptor antagonist) or saline (control) to evaluate how changes in muscarinic receptor activity modulate the adrenergic response to a heat exposure (n = 12). α- and β-adrenergic sweating was augmented in hot compared with temperate conditions (both P ≤ .014), albeit the relative increase was greater in β (~5.4-fold)- as compared to α (~1.5-fold)-adrenergic-mediated sweating response. However, both α- and β-adrenergic sweating was abolished by atropinization (P = .001). Endurance-trained men showed an augmentation in α- (P = .043) but not β (P = .960)-adrenergic sweating as compared to untrained men. Finally, a greater α- and β-adrenergic sweating response (both P ≤ .001) was measured in habitually active men than in women. We show that heat exposure augments α-and β-adrenergic sweating differently via mechanisms associated with altered muscarinic receptor activity. Sex and training status modulate this response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f62d73018dcd8f31492b9fc72295ea8 https://doi.org/10.1111/exd.14208 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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