Relationship between maternal and neonatal Staphylococcus aureus colonization
| Autor: | Weston Langdon, Andrew Alsentzer, Natalia Jimenez-Truque, Jesse P. Wright, Elizabeth J. Saye, Wenli Wang, C. Buddy Creech, Brian D. McKenna, Isaac P. Thomsen, Benjamin R. Saville, Sara K. Tedeschi, Sandra R. Arnold |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Pediatrics medicine.disease_cause Staphylococcal infections Group B Article Cohort Studies Internal medicine medicine Odds Ratio Humans Colonization Prospective Studies Pregnancy Bacteriological Techniques business.industry Age Factors Infant Newborn Staphylococcal Infections bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Tennessee Infectious Disease Transmission Vertical Nasal Mucosa Cross-Sectional Studies Staphylococcus aureus Pediatrics Perinatology and Child Health Cohort Vagina Female business Cohort study |
| Zdroj: | Pediatrics. 129(5) |
| ISSN: | 1098-4275 |
| Popis: | OBJECTIVE: The study aimed to assess whether maternal colonization with Staphylococcus aureus during pregnancy or at delivery was associated with infant staphylococcal colonization. METHODS: For this prospective cohort study, women were enrolled at 34 to 37 weeks of gestation between 2007 and 2009. Nasal and vaginal swabs for culture were obtained at enrollment; nasal swabs were obtained from women and their infants at delivery and 2- and 4-month postbirth visits. Logistic regression was used to determine whether maternal colonization affected infant colonization. RESULTS: Overall, 476 and 471 mother-infant dyads had complete data for analysis at enrollment and delivery, respectively. Maternal methicillin-resistant S aureus (MRSA) colonization occurred in 10% to 17% of mothers, with the highest prevalence at enrollment. Infant MRSA colonization peaked at 2 months of age, with 20.9% of infants colonized. Maternal staphylococcal colonization at enrollment increased the odds of infant staphylococcal colonization at birth (odds ratio; 95% confidence interval: 4.8; 2.4–9.5), hospital discharge (2.6; 1.3–5.0), at 2 months of life (2.7; 1.6–4.3), and at 4 months of life (2.0; 1.1–3.5). Similar results were observed for maternal staphylococcal colonization at delivery. Fifty maternal-infant dyads had concurrent MRSA colonization: 76% shared isolates of the same pulsed-field type, and 30% shared USA300 isolates. Only 2 infants developed staphylococcal disease. CONCLUSIONS: S aureus colonization (including MRSA) was extremely common in this cohort of maternal-infant pairs. Infants born to mothers with staphylococcal colonization were more likely to be colonized, and early postnatal acquisition appeared to be the primary mechanism. * Abbreviations: CA-MRSA — : community-associated methicillin-resistant Staphylococcus aureus GBS — : group B Streptococcus GEE — : generalized estimating equation MRSA — : methicillin-resistant Staphylococcus aureus MSSA — : methicillin-susceptible Staphylococcus aureus PCR — : polymerase chain reaction PVL — : Panton-Valentine leukocidin SSTIs — : skin and soft-tissue infections VUMC — : Vanderbilt University Medical Center |
| Databáze: | OpenAIRE |
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