Elevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgery
| Autor: | Elif Basagan-Mogol, Yesim Ozarda Ilcol, Ismail H. Ulus, Mete Cengiz |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Merkez Laboratuvarı., İlçöl, Özarda Yeşim, Başağan-Moğol, Elif, Cengiz, Mete, Ulus, İsmail Hakkı, AAL-8873-2021, D-5340-2015 |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Cardiac-surgery Bypass grafting Preoperative evaluation Clinical Biochemistry Choline Dimethylglycine Betaines Phosphopyruvate hydratase Cognitive decline On-pump Neuron specific enolase chemistry.chemical_compound Coronary artery bypass graft Protein S100B Protein blood level Coronary Artery Bypass Brain injury Coronary drtery bypass Middle aged Priority journal Biological markers Cardiopulmonary bypass Correlation analysis General Medicine Coronary artery surgery Rat-brain Mental deterioration Off pump coronary surgery Phospholipid medicine.anatomical_structure Plasma choline Female Brain diseases medicine.symptom S100 proteins Artery Free choline Human Adult medicine.medical_specialty Choleretic Cognition disorders Clinical article Enolase Off-pump S100 Calcium Binding Protein beta Subunit Blood analysis Article Lesion Disease association Cognitive dysfunction Upregulation medicine Postoperative period Humans Nerve growth factors Aged business.industry Time factors Biochemistry (medical) Neuron-specific enolase (NSE) S-100β Surgery Proton magnetic-resonance Postoperative complication Hippocampal acetylcholine-release Biological marker Nerve growth factor chemistry business Medical laboratory technology Neuron-specific enolase Enzyme blood level Controlled study Biomarkers |
| Popis: | The aims of this study were to determine circulating choline status and its relationship to circulating levels of S-100β protein and neuron-specific enolase, biochemical markers of cerebral injury and cognitive decline, after coronary artery bypass grafting (CABG) surgery. Preoperatively, patients scheduled for off-pump or on-pump CABG surgery had serum concentrations of 12.0±0.2 and 11.7±0.4μmol/L free choline and 2640±65 and 2675±115μmol/L phospholipid-bound choline, respectively. Serum free and bound choline levels decreased by 22–37% or 34–47% and 16–36% or 31–38% at 48h after off-pump or on-pump surgery, respectively. Serum S-100β and neuron-specific enolase increased from preoperative values of 0.083±0.009 and 6.3±0.2μg/L to 0.405±0.022 and 11.4±0.8μg/L, respectively, at 0h postoperatively and remained elevated for 48h after off-pump surgery. Serum free and bound choline concentrations were inversely correlated with the concentrations of S-100β (r=−0.798; p |
| Databáze: | OpenAIRE |
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