Responses of the rat chorda tympani nerve to glutamate-sucrose mixtures
| Autor: | S.D. Roper, Marion E. Frank, Bradley K. Formaker, J.R. Stapleton |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Taste medicine.medical_specialty Sucrose Physiology Monosodium glutamate Umami Stimulus (physiology) Amiloride Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Nerve Fibers Tongue Physiology (medical) Internal medicine Sodium Glutamate medicine Animals Dose-Response Relationship Drug Chemistry Glutamate receptor Drug Synergism Anatomy Taste Buds Sensory Systems Rats Electrophysiology medicine.anatomical_structure Endocrinology Sweetening Agents Food Additives Chorda Tympani Nerve medicine.drug |
| Zdroj: | Chemical senses. 29(6) |
| ISSN: | 0379-864X |
| Popis: | Monosodium glutamate (MSG) has a multifaceted, unusual taste to humans. Rats and other rodents also detect a complex taste to MSG. Responses of the chorda tympani nerve (CT) to glutamate applied to the front of the tongue were recorded in 13 anesthetized rats. Whole-nerve responses to 30 mM, 100 mM and 300 mM MSG mixed with 300 mM sucrose were recorded before and after adding 30 micro M amiloride to the rinse and stimulus solutions. Responses of CT single fibers were also recorded. Predictions from models of whole-nerve responses to binary mixtures were compared to the observed data. Results indicated that MSG-elicited CT responses have multiple sources, even in an amiloride-inhibited environment in rats. Those sources include responses of sucrose-sensitive CT neural units, which may provide the substrate for a sucrose-glutamate perceptual similarity, and responses of sucrose-insensitive CT neural units, which may respond synergistically to MSG-sucrose mixtures. |
| Databáze: | OpenAIRE |
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