| Autor: |
Yun-Fen, Chen, Si-Ying, Liu, Qi-Jiao, Cheng, Yu-Jiao, Wang, Shuang, Chen, Yi-Yang, Zhou, Xia, Liu, Zhi-Gang, Jiang, Wei-Wei, Zhong, Yi-Huai, He |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
World Journal of Gastroenterology. 28:3201-3217 |
| ISSN: |
1007-9327 |
| Popis: |
Endoplasmic reticulum (ER) stress contributes to the pathogenesis of chronic liver diseases, but how hepatocytes respond to ER stress has not been clarified. Alpha-fetoprotein (AFP) is secreted by hepatoma cells and elevated levels of serum AFP are associated with development of liver malignancies.To investigate whether and how AFP could regulate ER stress and hepatocyte injury.The distribution of AFP and the degrees of ER stress in liver tissues and liver injury were characterized by histology, immunohistochemistry, and Western blot in biopsied human liver specimens, two mouse models of liver injury and a cellular model. The levels of AFP in sera and the supernatants of cultured cells were quantified by chemiluminescence.High levels of intracellular AFP were detected in liver tissues, particularly in the necrotic areas, from patients with chronic liver diseases and mice after carbon tetrachloride (CClER stress upregulated intra-hepatocyte AFP expression by activating ATF6 during the process of liver injury and intracellular AFP attenuated hepatocyte apoptosis and necroptosis by alleviating ER stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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