Impact of a CART promoter genetic variation on plasma lipid profile in a general population
| Autor: | Audrey Guérardel, Philippe Froguel, Philippe Amouyel, Nicole Helbecque, Mouna Barat-Houari, Francis Vasseur, Dominique Cottel |
|---|---|
| Přispěvatelé: | Génétique des maladies multifactorielles (GMM), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Section of Genomic Medicine, Imperial College London, Genome Centre, Imperial College London-Hammersmith campus |
| Rok vydání: | 2006 |
| Předmět: |
Leptin
Male MESH: Lipoproteins LDL Endocrinology Diabetes and Metabolism MESH: Lipoproteins HDL Biochemistry MESH: Variation (Genetics) MESH: Cholesterol 0302 clinical medicine Endocrinology MESH: Nerve Tissue Proteins Promoter Regions Genetic MESH: Aged 2. Zero hunger 0303 health sciences education.field_of_study MESH: Middle Aged MESH: Polymorphism Single Nucleotide Middle Aged Neuropeptide Y receptor Lipids Lipoproteins LDL MESH: Promoter Regions (Genetics) MESH: Insulin Resistance Cholesterol lipids (amino acids peptides and proteins) Female Lipoproteins HDL Cart Adult medicine.medical_specialty Population MESH: Genetics Population 030209 endocrinology & metabolism Single-nucleotide polymorphism Nerve Tissue Proteins Biology Polymorphism Single Nucleotide Cocaine and amphetamine regulated transcript 03 medical and health sciences Internal medicine Genetics medicine Humans education Molecular Biology 030304 developmental biology Aged MESH: Humans Genetic Variation MESH: Adult Lipid metabolism MESH: Haplotypes MESH: Leptin MESH: Lipids MESH: Male Genetics Population [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics Haplotypes Insulin Resistance MESH: Female Lipoprotein |
| Zdroj: | Molecular Genetics and Metabolism Molecular Genetics and Metabolism, Elsevier, 2007, 90 (2), pp.199-204. ⟨10.1016/j.ymgme.2006.08.012⟩ |
| ISSN: | 1096-7192 1096-7206 |
| DOI: | 10.1016/j.ymgme.2006.08.012⟩ |
| Popis: | The cocaine and amphetamine regulated transcript (CART), an anorexigenic peptide responding to leptin, is expressed in various areas of the hypothalamus. The role of CART in humans and its potential contribution to abnormalities in feeding control are mostly unknown. Since CART plays an important role in the hypothalamic regulation of energy balance by reducing food intake and increasing lipid substrate utilization, it might affect cholesterol metabolism as Neuropeptide Y or pro-opiomelanocortin do. In the present work, we studied the potential effects of three SNPs of the CART promoter in a WHO–MONICA general population from North of France ( n =840), untreated for hypercholesterolemia, hypertension, or diabetes mellitus since any treatment is likely to interfere with lipoprotein/lipid variables. Our results show associations between these SNPs and plasma LDL-cholesterol level and the LDL/HDL ratio, a marker of atherogenicity. A haplotypic study suggests that these effects are mainly attributable to the functional SNP −3608C>T. Subjects bearing the −3608 C allele present a plasma lipid profile protective against atherogenesis: decrease of plasma LDL-cholesterol level ( p =0.001) and of the LDL/HDL ratio ( p =0.0003). This result offers new evidences for a potential implication of the CART gene in lipid metabolism and in atherogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect