ENANTIOPURE R(-)-3-AMINOISOBUTYRIC ACID SYNTHESIS USING Pseudomonas aeruginosa AS ENANTIOSPECIFIC BIOCATALYST
| Autor: | Enrique G. Oestreicher, R. R. Menezes, M. V. C. B. Cortes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Stereochemistry
β-Amino acid General Chemical Engineering lcsh:TP155-156 3-Aminoisobutyric acid chemistry.chemical_compound Enantiopure drug Stereospecificity chemistry Biocatalysis Yield (chemistry) Dihydropyrimidinase Pseudomonas aeruginosa Organic chemistry R(-)-3-aminoisobutyric acid Dihydrothymine lcsh:Chemical engineering Racemization |
| Zdroj: | Brazilian Journal of Chemical Engineering, Volume: 32, Issue: 1, Pages: 53-57, Published: MAR 2015 Brazilian Journal of Chemical Engineering, Vol 32, Iss 1, Pp 53-57 (2015) Brazilian Journal of Chemical Engineering v.32 n.1 2015 Brazilian Journal of Chemical Engineering Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
| Popis: | The main goal of this research was the synthesis of enantiopure R(-)-3-aminoisobutyric acid from dihydrothymine with good yield, high stereospecificity and relative simplicity. Seventy two percent yield of the product was obtained in three steps. Step one consisted of dihydrothymine racemization. Step two was a dihydropyrimidinase reaction involving the Pseudomonas aeruginosa 10145 bacterial strain as the biocatalyst. Step three was performed with a diazotization reaction. The bacteria's enzymes determined the stereochemistry of the process since the diazotization reaction did not interfere at this point. The results of this work provide an interesting method for the production of commercial β-amino acids from other substituteddihydrothymines. |
| Databáze: | OpenAIRE |
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