Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?

Autor:	R V Rebois, D R Warner, N S Basi
Rok vydání:	1997
Předmět:	Gs alpha subunit GTPase-activating protein Effector G protein Protein Conformation Cell Biology Biology Cell biology Enzyme Activation G beta-gamma complex GTP-Binding Proteins Heterotrimeric G protein G12/G13 alpha subunits Animals G alpha subunit Signal Transduction
Zdroj:	Cellular signalling. 9(2)
ISSN:	0898-6568
Popis:	Heterotrimeric (alpha beta gamma) G proteins mediate a variety of signal transduction events in virtually every cell of every eukaryotic organism. The predominant hypothesis is that dissociation of the alpha-subunit from the G beta gamma-subunit complex necessarily accompanies the activation of these proteins, and that the alpha-subunit is primarily responsible for regulating the response of effector molecules. However, there is increasing evidence that both the alpha-subunit and the beta gamma-subunit complex function in regulating effector activity. Furthermore, data for some G proteins suggest that they function as activated heterotrimers rather than as dissociated subunits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f51034f3840a2f09a4eb8e7f8a9af3b https://pubmed.ncbi.nlm.nih.gov/9113413 Zobrazit plný text záznamu Full Text from ScienceDirect