Induced alteration of rat erythrocyte membrane with effect of pyrethroid based compounds
| Autor: | Daoud Ali, Hui Liu, Narendra Maddu, Hamzah A. Alghamdi, Suliman Y. Al Omar, Umeshareen Shaik, Shaik Althaf Hussain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine medicine.medical_specialty Phospholipid 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Membrane fluidity Pyrethroids Erythrocyte membrane lcsh:QH301-705.5 Super oxide dismutase Cholesterol Prallethrin Glutathione 030104 developmental biology Endocrinology chemistry lcsh:Biology (General) Uric acid lipids (amino acids peptides and proteins) Original Article General Agricultural and Biological Sciences Tetramethrin 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 27, Iss 12, Pp 3669-3675 (2020) |
| ISSN: | 1319-562X |
| Popis: | The effects of tetramethrin and prallethrin exposure on plasma total proteins, free amino acids, albumins, urea, urea nitrogen, uric acid, creatinine were tested. Serum SGOT, SGPT and lipid profile, antioxidants super oxide dismutase (SOD), catalase, GSH, G-Px, phospholipids, cholesterol, C/P ratio in membranes of erythrocyte and membrane fluidity were analyzed. The reason of the study were analyzed to examine the possessions of mosquito repellent pyrethroid (MRP) based compounds tetramethrin and prallethrin exposure on plasma profile, antioxidant status of erythrocyte membrane, membrane fluidity in male Wistar rats. We tested chronically for three months exposure every day (continuously for 8-10 hours per day by inhalation) of tetramethrin and prallethrin markedly available (MRP) repellents treated on male Wistar rats. Our results confirmed that tetrarmethrin and prallethrin treatment effect of plasma profile alterations, and lipid homeostasis mechanism in Red Blood cells (RBCs). Tetramethrin and prallethrin treatment significantly increased in erythrocyte membrane phospholipids and decreased levels of cholesterol with no change of protein content, increased C/P ration levels. Inhalation of tetramethrin and prallethrin stimulate plasma biophysical and biochemical modify SGOT, SGPT, erythrocyte membrane cholesterol and phospholipid levels, individual phospholipids and membrane fluidity of exposure rats compared to controls. |
| Databáze: | OpenAIRE |
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