Hair Trace Elements are Associated with Increased Thyroid Volume in Schoolchildren with Goiter
| Autor: | Anatoly V. Skalny, Gulbakit K. Koshmaganbetova, Narseta Mickuviene, Khatima I. Kudabayeva, Alexey A. Tinkov, Margarita G. Skalnaya |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Goiter Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland chemistry.chemical_element 030209 endocrinology & metabolism Normal values 010501 environmental sciences Iodine 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Child Ultrasound scanner 0105 earth and related environmental sciences Chemistry Biochemistry (medical) Thyroid General Medicine Organ Size medicine.disease Trace Elements medicine.anatomical_structure Endocrinology Correlation analysis Female Hair |
| Zdroj: | Biological trace element research. 174(2) |
| ISSN: | 1559-0720 |
| Popis: | The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid volume was measured using an ultrasound scanner and compared to the previously calculated normal values. The obtained data indicate that children with goiter were characterized by 20 and 15 % lower values of hair Cr and Zn, and 66, 42, 16, and 42 % higher hair levels of I, Mn, Si, and V as compared to the control values, respectively. Moreover, children with goiter were characterized by a twofold higher hair B levels than the control ones. Correlation analysis demonstrated a significant direct association only between thyroid volume and hair B (r = 0.482; p = 0.004), I (r = 0.393; p = 0.021), Mn (r = 0.364; p = 0.034), and Si (r = 0.446; p = 0.008) levels. It is also notable that hair I content was interrelated only with Si (r = 0.346; p = 0.045). No significant correlation was detected between I and B (r = 0.250; p = 0.155) and Mn (r = 0.076; p = 0.669) in hair of children. It is hypothesized that an increase in thyroid volume in children is associated with a complex interplay of iodine with other trace elements rather than with altered iodine status itself. |
| Databáze: | OpenAIRE |
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